Pentagamavunon-1
中文名称 | Pentagamavunon-1 |
---|---|
中文同义词 | 化合物 PENTAGAMAVUNON-1 |
英文名称 | Pentagamavunon-1 |
英文同义词 | Pentagamavunon-1;Cyclopentanone, 2,5-bis[(4-hydroxy-3,5-dimethylphenyl)methylene]- |
CAS号 | 27060-70-4 |
分子式 | C23H24O3 |
分子量 | 348.43 |
EINECS号 | |
相关类别 | |
Mol文件 | 27060-70-4.mol |
结构式 | ![]() |
Pentagamavunon-1 性质
沸点 | 562.1±50.0 °C(Predicted) |
---|---|
密度 | 1.232±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:50 mg/mL(143.50 mM) |
酸度系数(pKa) | 10.12±0.40(Predicted) |
形态 | 固体 |
颜色 | 浅黄至黄色 |
Pentagamavunon-1 (PGV-1, 1, 2.5, 5, 7.5, 10, 15, and 20 µM) enhances cytotoxic effect of 5-FU on WiDr cells.
Pentagamavunon-1 (PGV-1, 1, 2.5, 5, and 10 µM) shows different effects on cell cycle progression and induces G2/M arrest.
Cell Viability Assay.
Cell Line: | Human colon carcinoma WiDr. |
Concentration: | 1, 2.5, 5, 7.5, 10, 15, and 20 µM. |
Incubation Time: | 6, 12, 24, and 48 hours. |
Result: | Significantly enhanced the cytotoxicity of 5-FU on WiDr cells at various concentrations during 6, 12, 24, and 48 h incubation. |
Cell Cycle Analysis.
Cell Line: | WiDr cells. |
Concentration: | 1, 2.5, 5, and 10 µM. |
Incubation Time: | 24 h. |
Result: | The non-treated WiDr cells showed cell accumulation in G1, S, and G2/M phase about 50.85%, 36.11% and 13.04%, respectively. |
Pentagamavunon-1 (PGV-1, po, 20 mg/kg) exhibits significant anti-tumor activity in PDX model, without obvious toxicity.
Animal Model: | Human cancer cells in a xenograf mouse model. |
Dosage: | 20mg/kg. |
Administration: | P.O. every 2 days for 20 days. |
Result: | Exhibited little decrease in body weight, nor a decrease in white and red blood cell counts in peripheral blood, nor any other efects in behavior and macroscopic appearance. Thus, PGV-1 was sufciently potent to suppress tumor formation in vivo, but exhibited little or no obvious adverse effects on the normal lineage of cells. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-136477 | Pentagamavunon-1 | 5 mg | 600元 | |
2024/08/19 | HY-136477 | Pentagamavunon-1 Pentagamavunon-1 | 27060-70-4 | 10mM * 1mLin DMSO | 660元 |