伊马咪啶
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- CAS号:
- 84243-58-3
- 英文名:
- IMAZODAN
- 英文别名:
- Cl 914;CI-914;IMAZODAN;4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]pyridazin-3(2H)-one;4,5-DIHYDRO-6-[4-(1H-IMIDAZOL-1-YL)PHENYL]-3(2H)-PYRIDAZINONE;4,5-Dihydro-6-[4-(1H-imidazol-1-y1)phenyl]-3(2H)-pyridazinone;6-(4-(1H-imidazol-1-yl)phenyl)-4,5-dihydropyridazin-3(2H)-one;3(2H)-Pyridazinone, 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-;6-[4-(1H-Imidazole-1-yl)phenyl]-2,3,4,5-tetrahydropyridazine-3-one;4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone, Cl 914
- 中文名:
- 伊马咪啶
- 中文别名:
- 伊马唑旦;伊马咪啶;亚马佐旦;咪苯嗪酮;伊马唑啶;6-(4-(1H-咪唑-1-基)苯基)-4,5-二氢哒嗪-3(2H)-酮;4,5-二氢-6-[4-(1H-咪唑-1-基)苯基]-3(2H)-哒嗪酮
- CBNumber:
- CB7722693
- 分子式:
- C13H12N4O
- 分子量:
- 240.26
- MOL File:
- 84243-58-3.mol
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伊马咪啶化学性质
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熔点:
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218℃
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密度:
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1.34±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO: 50 mg/mL, clear, yellow
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酸度系数(pKa):
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13.48±0.40(Predicted)
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颜色:
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yellow, powder
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伊马咪啶性质、用途与生产工艺
化学性质
白色固体,熔点213--214℃。
盐酸伊马唑旦(Imazodan Hydrochloride):C13H12N4O?HCl。熔点290~291℃。
用途
非强心苷、非儿茶酚胺的强心药物。用于心力衰竭。
生产方法
氟苯、无水三氯化铝和二氯甲烷混合,搅拌下加入琥珀酸酐。加毕回流,得4-(4-氟苯基)-4-氧代丁酸,收率62.2%。将其和咪唑及二甲亚砜混合后,滴加到甲醇钠中。105℃反应得4-[4-(1H-咪唑-1-基)苯基1-4-氧代丁酸,收率61.5%。然后和水合肼在乙醇中反应,得伊马唑旦,收率92%,熔点212--213℃
伊马咪啶
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84243-58-3, 伊马咪啶 相关搜索:
- 药物
- 心脑血管药物
- 强心药
- Phosphodiesterase Inhibitors
- G Proteins and Cyclic Nucleotides
- Cyclic Nucleotide Metabolism
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- 6-(4-(1H-咪唑-1-基)苯基)-4,5-二氢哒嗪-3(2H)-酮
- 伊马唑啶
- 4,5-二氢-6-[4-(1H-咪唑-1-基)苯基]-3(2H)-哒嗪酮
- 伊马唑旦
- 伊马咪啶
- 亚马佐旦
- 咪苯嗪酮
- 84243-58-3
- 3(2H)-Pyridazinone, 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-
- 4,5-Dihydro-6-[4-(1H-imidazol-1-y1)phenyl]-3(2H)-pyridazinone
- 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone, Cl 914
- 6-(4-(1H-imidazol-1-yl)phenyl)-4,5-dihydropyridazin-3(2H)-one
- Cl 914
- 6-[4-(1H-Imidazole-1-yl)phenyl]-2,3,4,5-tetrahydropyridazine-3-one
- 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]pyridazin-3(2H)-one
- 4,5-DIHYDRO-6-[4-(1H-IMIDAZOL-1-YL)PHENYL]-3(2H)-PYRIDAZINONE
- CI-914
- IMAZODAN