RF9
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- CAS号:
- 876310-60-0
- 英文名:
- 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE
- 英文别名:
- RD9;RF 9;RF 9 TFA;RF9Trifluoroacetate;RF9 trifluoroacetate salt;1-Adamantanecarbonyl-Arg-Phe-NH2;2-Adamantanecarbonyl-Arg-Phe-NH2;2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE;1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt;L-Phenylalaninamide, N2-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl-
- 中文名:
- RF9
- 中文别名:
- RF9|||RF-9;化合物 T16738;神经肽FF受体拮抗剂RF9;N2-(金刚烷-1-基羰基)-L-精氨酰基-L-苯丙氨酰胺;2-金刚烷羰基-精氨酸-苯丙氨酸-NH2三氟乙酸酯(RF 9 TFA)
- CBNumber:
- CB7847749
- 分子式:
- C26H38N6O3
- 分子量:
- 482.62
- MOL File:
- 876310-60-0.mol
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RF9化学性质
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密度:
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1.42±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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H2O: soluble20mg/mL
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酸度系数(pKa):
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14.53±0.20(Predicted)
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形态:
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solid
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颜色:
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White
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RF9性质、用途与生产工艺
RF9 是一种有效且有选择性的神经肽 FF 受体 (Neuropeptide FF receptor) 拮抗剂 ,对于 hNPFF1R 和 hNPFF2R 的 Ki 值分别为 58 和 7 nM。
hNPFF1R
58 nM (Ki)
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hNPFF2R
75 nM (Ki)
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RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells.
RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance.
RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9.
Animal Model:
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Rats.
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Dosage:
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0.1 mg/kg.
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Administration:
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S.C. 30 min before 0.3 mg/kg heroin or saline on basal nociceptive threshold in rats.
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Result:
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Opposed to delaye heroin-induced hyperalgesia and associated tolerance.
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RF9
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-107382 | 2-ADAMANTANECARBONYL-ARG-PHE-NH2 RF9 | 876310-60-0 | 1mg | 990元 |
2024/04/30 | HY-107382 | 2-ADAMANTANECARBONYL-ARG-PHE-NH2 RF9 | 876310-60-0 | 10 mM * 1 mLin DMSO | 3079元 |
876310-60-0, RF9 相关搜索:
- 药靶配体
- 目录多肽
- 多肽
- 目录肽
- 标准品
- C26H38N6O3
- RF9|||RF-9
- 2-金刚烷羰基-精氨酸-苯丙氨酸-NH2三氟乙酸酯(RF 9 TFA)
- N2-(金刚烷-1-基羰基)-L-精氨酰基-L-苯丙氨酰胺
- 化合物 T16738
- 神经肽FF受体拮抗剂RF9
- 876310-60-0
- RF 9 TFA
- RF9Trifluoroacetate
- L-Phenylalaninamide, N2-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl-
- RD9
- RF9 trifluoroacetate salt
- 1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt
- 1-Adamantanecarbonyl-Arg-Phe-NH2
- RF 9
- 2-Adamantanecarbonyl-Arg-Phe-NH2
- 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE