未消化麦醇溶蛋白肽GLIADIN P31-43
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- CAS号:
- 176326-01-5
- 英文名:
- L-Tyrosine, L-leucylglycyl-L-glutaminyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-phenylalanyl-L-prolyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-prolyl-
- 英文别名:
- Gliadin p31-43;L-Tyrosine, L-leucylglycyl-L-glutaminyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-phenylalanyl-L-prolyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-prolyl-
- 中文名:
- 未消化麦醇溶蛋白肽GLIADIN P31-43
- 中文别名:
- 未消化麦醇溶蛋白肽GLIADIN P31-43
- CBNumber:
- CB78590546
- 分子式:
- C71H102N18O20
- 分子量:
- 1527.68
- MOL File:
- 176326-01-5.mol
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未消化麦醇溶蛋白肽GLIADIN P31-43化学性质
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沸点:
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1968.7±65.0 °C(Predicted)
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密度:
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1.371±0.06 g/cm3(Predicted)
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形态:
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Solid
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酸度系数(pKa):
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3.11±0.10(Predicted)
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颜色:
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White to off-white
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未消化麦醇溶蛋白肽GLIADIN P31-43性质、用途与生产工艺
Gliadin p31-43 是一种未消化的麦醇溶蛋白肽,可诱导肠道内的先天性免疫反应并干扰内吞运输。Gliadin p31-43 可用于乳糜泻的研究。
Gliadin p31-43 (100 μg/mL; 30 minutes-6 hours) treatment induces the MyD88/TLR7 complexes, and activates downstream signalling by activating MAPKs, ERK, JNK and p38). Gliadin p31-43 increases the levels of the phosphorylated forms of pY-ERK, JNK (pY-JNK) and p38 (pY-p38).
Gliadin p31-43 treatment increases NF-κB phosphorylation in CaCo-2 cells from 0.45 in control cells to 0.86. Gliadin p31-43 treatment induces a significant increase in levels of the MxA protein. The levels of the IFN-α 7 and 17 mRNAs are also analysed after Gliadin p31-43 treatment.
In CaCo-2 cells, Gliadin p31-43 localizes to the early endosomes and delays vesicular trafficking. Gliadin p31-43 interferes with the correct localization of the growth factor regulated tyrosine kinase substrate (HRS) to early endosomes, delaying the maturation of the endocytic vesicles.
Western Blot Analysis
Cell Line:
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CaCo-2 cells
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Concentration:
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100 μg/mL
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Incubation Time:
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30 minutes, 3 hours, 6 hours
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Result:
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Showed the increase in formation of the MyD88/TLR7 complex, and increased in the level of TLR7.
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Gliadin p31-43 (10 μg; intraluminally injection) shows a sequence-specific spontaneous ability to form structured oligomers and aggregates in vitro and induced activation of the apoptosis-associated speck-like (ASC) complex.
The increment of IL-1β indicates the activation of the inflammasome caspase-1 pathway in the small intestine mucosa by oral administration of Gliadin p31-43 (20 μg) in wild type C57Bl/6 mice. Gliadin p31-43 has an intrinsic propensity to form oligomers which trigger the NLRP3 inflammasome.
未消化麦醇溶蛋白肽GLIADIN P31-43
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-P3151 | Gliadin p31-43 | | 1 mg | 2200元 |
2024/01/25 | HY-P3151 | Gliadin p31-43 | 176326-01-5 | 5 mg | 5500元 |
未消化麦醇溶蛋白肽GLIADIN P31-43
生产厂家
176326-01-5, 未消化麦醇溶蛋白肽GLIADIN P31-43 相关搜索:
- 目录肽
- C71H102N18O20
- 未消化麦醇溶蛋白肽GLIADIN P31-43
- 176326-01-5
- Gliadin p31-43
- L-Tyrosine, L-leucylglycyl-L-glutaminyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-phenylalanyl-L-prolyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-prolyl-