未消化麦醇溶蛋白肽GLIADIN P31-43
| 中文名称 | 未消化麦醇溶蛋白肽GLIADIN P31-43 |
|---|---|
| 中文同义词 | 未消化麦醇溶蛋白肽GLIADIN P31-43 |
| 英文名称 | L-Tyrosine, L-leucylglycyl-L-glutaminyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-phenylalanyl-L-prolyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-prolyl- |
| 英文同义词 | L-Tyrosine, L-leucylglycyl-L-glutaminyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-phenylalanyl-L-prolyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-prolyl-;Gliadin p31-43 |
| CAS号 | 176326-01-5 |
| 分子式 | C71H102N18O20 |
| 分子量 | 1527.68 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 176326-01-5.mol |
| 结构式 |  |
未消化麦醇溶蛋白肽GLIADIN P31-43 性质
| 沸点 | 1968.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.371±0.06 g/cm3(Predicted) |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.11±0.10(Predicted) |
| 颜色 | 白色至米白色 |
Gliadin p31-43 (100 μg/mL; 30 minutes-6 hours) treatment induces the MyD88/TLR7 complexes, and activates downstream signalling by activating MAPKs, ERK, JNK and p38). Gliadin p31-43 increases the levels of the phosphorylated forms of pY-ERK, JNK (pY-JNK) and p38 (pY-p38).
Gliadin p31-43 treatment increases NF-κB phosphorylation in CaCo-2 cells from 0.45 in control cells to 0.86. Gliadin p31-43 treatment induces a significant increase in levels of the MxA protein. The levels of the IFN-α 7 and 17 mRNAs are also analysed after Gliadin p31-43 treatment.
In CaCo-2 cells, Gliadin p31-43 localizes to the early endosomes and delays vesicular trafficking. Gliadin p31-43 interferes with the correct localization of the growth factor regulated tyrosine kinase substrate (HRS) to early endosomes, delaying the maturation of the endocytic vesicles.
Western Blot Analysis
| Cell Line: | CaCo-2 cells |
| Concentration: | 100 μg/mL |
| Incubation Time: | 30 minutes, 3 hours, 6 hours |
| Result: | Showed the increase in formation of the MyD88/TLR7 complex, and increased in the level of TLR7. |
Gliadin p31-43 (10 μg; intraluminally injection) shows a sequence-specific spontaneous ability to form structured oligomers and aggregates in vitro and induced activation of the apoptosis-associated speck-like (ASC) complex.
The increment of IL-1β indicates the activation of the inflammasome caspase-1 pathway in the small intestine mucosa by oral administration of Gliadin p31-43 (20 μg) in wild type C57Bl/6 mice. Gliadin p31-43 has an intrinsic propensity to form oligomers which trigger the NLRP3 inflammasome.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-P3151 | Gliadin p31-43 | 1 mg | 2200元 | |
| 2024/01/25 | HY-P3151 | Gliadin p31-43 | 176326-01-5 | 5 mg | 5500元 |