丁福明
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- CAS号:
- 692-13-7
- 英文名:
- 1-butylbiguanide
- 英文别名:
- Buformin;DBV;W 37;H 224;Glybigid;Butformin;Buformine;Dibetos B;Butyldiguanide;Butylbiguanide
- 中文名:
- 丁福明
- 中文别名:
- 丁双胍;丁福明;甲醇中丁二胍;化合物 T23837
- CBNumber:
- CB7913312
- 分子式:
- C6H15N5
- 分子量:
- 157.2168
- MOL File:
- 692-13-7.mol
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丁福明化学性质
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熔点:
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174-176 °C
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沸点:
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271.89°C (rough estimate)
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密度:
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1.0291 (rough estimate)
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折射率:
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1.8070 (estimate)
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酸度系数(pKa):
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12.27±0.10(Predicted)
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丁福明性质、用途与生产工艺
Buformin (1-Butylbiguanide) 是一种有效的 AMPK 活化剂，也是具有口服活性的双胍类降血糖试剂 (antidiabetic agent)。Buformin 降低肝糖异生并降低血糖生成。Buformin 也具有抗癌活性，可以应用于癌症研究，如宫颈癌、乳腺癌等。
Buformin (0-10 mM; 5 days) inhibits SKBR3 and BT474 cells growth as a concentration-dependent manner, exhibits IC
50
values of 246.7 μM and 98.6 μM for erbB-2-overexpressing SKBR3 and BT474 cells, respectively.Buformin (0-3 mM; 48 hours) increases the percentage of cells in G0/G1 phase and reduced the percentage of cells in S phase, especially in the SKBR3 cells.Buformin (0-3 mM; 24 hours) suppresses RTK activation, including erbB-2 and IGF1R signaling downstream, and Akt activation/phosphorylation is inhibited in both SKBR3 and BT474 cells.
Cell Viability Assay
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Cell Line:
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ErbB-2-overexpressing SKBR3 and BT474 cells
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Concentration:
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0 μM, 1 μM, 3 μM, 10 μM, 30 μM, 100 μM, 300 μM, 1, 3, or 10 mM
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Incubation Time:
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5 days
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Result:
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Reduced cell viability in erbB-2-overexpressing breast cells.
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Cell Cycle Analysis
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Cell Line:
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ErbB-2-overexpressing SKBR3 and BT474 cells
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Concentration:
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0.5 mM; 1 mM; 3 mM
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Incubation Time:
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48 hours
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Result:
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Increased cells arresting in G0/G1 phase.
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Western Blot Analysis
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Cell Line:
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ErbB-2-overexpressing SKBR3 and BT474 cells
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Concentration:
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0 mM, 0.1 mM, 0.3 mM, 1 mM, or 3 mM
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Incubation Time:
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24 hours
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Result:
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Decreased p-AMPK, p-p706S, p-ERK1/2 expression in a concentration-dependent manner.
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Buformin (oral administation; 7.6 mmol/kg of chow; 7 days) exhibits significantly reduced tumor volumes and weights, and hinders mammary morphogenesis and proliferation in MMTV-erbB-2 transgenic mice
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Animal Model:
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Female MMTV-erbB-2 transgenic mice
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Dosage:
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7.6 mmol/kg
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Administration:
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Oral administation; 7 days
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Result:
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Inhibited mammary syngeneic tumor growth in MMTV-erbB-2 transgenic mice.
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类别
有毒物品
毒性分级
高毒
急性毒性
口服-小鼠 LD50: 300 毫克/公斤; 腹腔-小鼠 LD50: 140 毫克/公斤
可燃性危险特性
热分解排出有毒氮氧化物烟雾
储运特性
仓库通风低温干燥; 与食品原料分开存放
灭火剂
水,干粉, 二氧化碳, 泡沫
丁福明
上下游产品信息
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下游产品
丁福明
生产厂家
全球有 26家供应商
丁福明国内生产厂家
692-13-7, 丁福明 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- 抑制剂
- 医药原料
- C6H15N5
- 500-20-3
- 甲醇中丁二胍
- 化合物 T23837
- 丁双胍
- 丁福明
- 692-13-7
- N-butylimidodicarbonimidic DiamideDiscontinued, see B689520
- Buformin
- DBV
- 1-butylbiguanide USP/EP/BP
- Imidodicarbonimidicdiamide, N-butyl-
- 2-butyl-1-(diaminomethylidene)guanidine
- 2-butyl-1-(diaminomethylene)guanidine
- 1-[bis(azanyl)methylidene]-2-butyl-guanidine
- 1-butylbiguanide
- W 37
- N-Butyl-idodicarbonimidic Diamide
- Butformin
- Buformine
- Buformin (base and/or unspecified salts)
- N-BUTYLBIGUANIDINE
- N1-Butylbiguanide
- H 224
- Glybigid
- Dibetos B
- Butyldiguanide
- Butylbiguanide