BIMOSIAMOSE DISODIUM
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- CAS号:
- 187269-60-9
- 英文名:
- Bimosiamose disodium
- 英文别名:
- TBC-1269Z;Bimosiamose disodium
- 中文名:
- BIMOSIAMOSE DISODIUM
- 中文别名:
- 比莫西糖二钠盐;化合物 T14573
- CBNumber:
- CB81401695
- 分子式:
- C46H52Na2O16
- 分子量:
- 906.87502
- MOL File:
- 187269-60-9.mol
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BIMOSIAMOSE DISODIUM性质、用途与生产工艺
Bimosiamose disodium (TBC-1269Z) 是一种非寡糖泛-selectin 抑制剂，对 E-selectin，P-selectin 和 L-selectin 的 IC50 分别为 88 μM，20 μM 和 86μM。Bimosiamose disodium 具有抗炎作用。
IC50: 88 μM (E-selectin), 20 μM (P-selectin), and 86 μM (L-selectin)
Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils.
Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved.
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Animal Model:
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Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)
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Dosage:
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25 mg/kg
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Administration:
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Intravenous injection
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Result:
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Showed a significant increase in survival compared with controls.
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BIMOSIAMOSE DISODIUM
上下游产品信息
上游原料
下游产品
BIMOSIAMOSE DISODIUM
生产厂家
187269-60-9, BIMOSIAMOSE DISODIUM 相关搜索:
- 对照品
- 化合物 T14573
- 比莫西糖二钠盐
- 187269-60-9
- TBC-1269Z
- Bimosiamose disodium