BIMOSIAMOSE DISODIUM
中文名称 | BIMOSIAMOSE DISODIUM |
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中文同义词 | 比莫西糖二钠盐;化合物 T14573 |
英文名称 | Bimosiamose disodium |
英文同义词 | Bimosiamose disodium;TBC-1269Z |
CAS号 | 187269-60-9 |
分子式 | C46H52Na2O16 |
分子量 | 906.87502 |
EINECS号 | |
相关类别 | 对照品 |
Mol文件 | 187269-60-9.mol |
结构式 |
BIMOSIAMOSE DISODIUM 性质
熔点 | 243-245° |
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IC50: 88 μM (E-selectin), 20 μM (P-selectin), and 86 μM (L-selectin)
Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils.
Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved.
Animal Model: | Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R) |
Dosage: | 25 mg/kg |
Administration: | Intravenous injection |
Result: | Showed a significant increase in survival compared with controls. |