网站主页 >> CAS数据库列表 >> 3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺
3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺
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- CAS号:
- 252003-65-9
- 英文名:
- CP-547632
- 英文别名:
- CS-1957;CP-547632;CP-547632(CP 547632);CP-547632 (PAN-90806);3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox;3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami;3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide;3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide;3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide;3-[(4-broMo-2,6-difluorophenyl)Methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]aMino]carbonyl]aMino]-4-isothiazolecarboxaMide
- 中文名:
- 3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺
- 中文别名:
- 化合物 T10870L;化合物 CP-547632;3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺
- CBNumber:
- CB82473822
- 分子式:
- C20H24BrF2N5O3S
- 分子量:
- 532.4
- MOL File:
- 252003-65-9.mol
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3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺化学性质
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沸点:
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548.6±50.0 °C(Predicted)
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密度:
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1.532
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储存条件:
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2-8°C
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溶解度:
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DMSO: 94 mM
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形态:
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A solid
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酸度系数(pKa):
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12.50±0.70(Predicted)
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颜色:
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White to light yellow
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3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺性质、用途与生产工艺
CP-547632 是一种口服有效的，ATP 竞争性的 VEGFR-2 和 FGF 激酶抑制剂，IC50 分别为 11 nM 和 9 nM。CP-547632 对 VEGFR2 和 bFGF 的选择性高于 EGFR，PDGFRβ 和相关的酪氨酸激酶 (TKs)。CP-547632 具有抗肿瘤作用。
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VEGFR-2
11 nM (IC
50
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FGFR
9 nM (IC
50
)
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CP-547632 (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion, with an IC
50
value of 6 nM.
Western Blot Analysis
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Cell Line:
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Serum-deprived cells
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Concentration:
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1, 4, 16, 63, 250, 1000 nM
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Incubation Time:
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1 hours
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Result:
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Inhibited VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion.
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CP-547632 (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.
CP-547632 (oral; 50 mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for 12 hours.
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Animal Model:
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Athymic female mice (CD-1 nu/nu) bearing tumors (75-150 mm in size)
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Dosage:
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6.25, 12.5, 25, 50, 100 mg/kg
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Administration:
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PO; daily; 10-24 days
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Result:
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Caused a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.
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Animal Model:
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Female athymic mice bearing H-Ras tumor
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Dosage:
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50 mg/kg
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Administration:
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Oral
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Result:
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A single oral dose of 50 mg/kg yielded plasma concentrations above 500 ng/ml for 12 hours.
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3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-13302 | CP-547632 | | 1 mg | 431元 |
| 2024/08/19 | HY-13302 | 3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺
CP-547632 | 252003-65-9 | 5mg | 850元 |
3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺
生产厂家
252003-65-9, 3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺 相关搜索:
- 抑制剂
- C20H24BrF2N5O3S
- 化合物 CP-547632
- 化合物 T10870L
- 3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺
- 252003-65-9
- 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide
- CP-547632 (PAN-90806)
- CS-1957
- 3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide
- 3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox
- 3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami
- 3-[(4-broMo-2,6-difluorophenyl)Methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]aMino]carbonyl]aMino]-4-isothiazolecarboxaMide
- CP-547632(CP 547632)
- 4-Isothiazolecarboxamide, 3-((4-bromo-2,6-difluorophenyl)methoxy)-5-((((4-(1-pyrrolidinyl)butyl)amino)carbonyl)amino)-
- 3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide
- CP-547632