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CP-547632

CP-547632 구조식 이미지

카스 번호:: 252003-65-9

상품명:: CP-547632

동의어(영문):: CS-1957;CP-547632;CP-547632(CP 547632);CP-547632 (PAN-90806);3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox;3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami;3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide;3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide;3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide;3-[(4-broMo-2,6-difluorophenyl)Methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]aMino]carbonyl]aMino]-4-isothiazolecarboxaMide

CBNumber:: CB82473822

분자식:: C20H24BrF2N5O3S

포뮬러 무게:: 532.4

MOL 파일:: 252003-65-9.mol

속성

안전

용도

공급 업체 62

CP-547632 속성

끓는 점: 548.6±50.0 °C(Predicted)

밀도: 1.532

저장 조건: 2-8°C

용해도: DMSO: 94 mM

물리적 상태: 고체

산도 계수 (pKa): 12.50±0.70(Predicted)

색상: White to light yellow

안전

CP-547632 C화학적 특성, 용도, 생산

개요

CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC₅₀ values of 11 and 9 nM, respectively, in an enzyme assay. It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor β (PDGFRβ), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC₅₀ = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC₅₀ = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice.

CP-547632 준비 용품 및 원자재

원자재

준비 용품

CP-547632 (hydrochloride)

CP-547632 공급 업체

글로벌( 62)공급 업체

공급자	전화	이메일	국가	제품 수	이점
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Shanghai Likang New Materials Co., Limited	+86-16631818819 +86-17736933208	3684455296@qq.com	China	9311	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd	15658004993	1900830611@qq.com	China	956	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	6008	61
China Kouting Group Limited	+86 (21) 5811-6473 5811-6475	sales@koutingchina.com	China	496	60

CP-547632 관련 검색:

1,1-DIBROMOTETRAFLUOROETHANE α-Bromo-2,3,4,5,6-pentafluorotoluene