287194-38-1
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- CAS号:
- 287194-38-1
- 英文名:
- Cis(+/-)-2-hydroxy-N-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzaMide
- 英文别名:
- rel-DHMEQ;DHMEQ (racemate);TRANS-2-HYDROXY-N-(2-HYDROXY-5-OXO-7-OXABICYCLO[4.1.0]HEPT-3-EN-3-YL)BENZAMIDE;2-hydroxy-N-[(1S,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide;Cis(+/-)-2-hydroxy-N-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzaMide;Benzamide, 2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-, rel-
- 中文名:
- 287194-38-1
- 中文别名:
- 化合物 T11018;化合物 DHMEQ RACEMATE
- CBNumber:
- CB82595856
- 分子式:
- C13H11NO5
- 分子量:
- 261.23014
- MOL File:
- 287194-38-1.mol
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287194-38-1化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 32 mg/mL (122.50 mM)
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287194-38-1性质、用途与生产工艺
DHMEQ racemate 是一种 NF-κB 抑制剂。 DHMEQ racemate 抑制 NF-κB 的活性低于 (-)-DHMEQ。
DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibits TNF-a-induced NF-kB activation. (-)-DHMEQ is more potent and less toxic than DHMEQ racemate.
The antiarthritic effects of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) are examined on type-II collagen-induced arthritis in DBA1/J mice. This animal model is widely used for evaluation of antirheumatic drugs because of its pathological similarities to human rheumatoid arthritis. The arthritis is elicited and scored. (-)-DHMEQ markedly inhibits type-II-collagen-induced arthritis in mice, whereas DHMEQ racemate tends to only slightly inhibit it.
287194-38-1
上下游产品信息
上游原料
下游产品
287194-38-1, 287194-38-1 相关搜索:
- 抑制剂
- 化合物 DHMEQ RACEMATE
- 化合物 T11018
- 287194-38-1
- Benzamide, 2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-, rel-
- 2-hydroxy-N-[(1S,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide
- TRANS-2-HYDROXY-N-(2-HYDROXY-5-OXO-7-OXABICYCLO[4.1.0]HEPT-3-EN-3-YL)BENZAMIDE
- rel-DHMEQ
- DHMEQ (racemate)
- Cis(+/-)-2-hydroxy-N-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzaMide