287194-38-1
中文名称 | 287194-38-1 |
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中文同义词 | 化合物 T11018 |
英文名称 | Cis(+/-)-2-hydroxy-N-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzaMide |
英文同义词 | Cis(+/-)-2-hydroxy-N-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzaMide;DHMEQ (racemate);rel-DHMEQ;TRANS-2-HYDROXY-N-(2-HYDROXY-5-OXO-7-OXABICYCLO[4.1.0]HEPT-3-EN-3-YL)BENZAMIDE;2-hydroxy-N-[(1S,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide;Benzamide, 2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-, rel- |
CAS号 | 287194-38-1 |
分子式 | C13H11NO5 |
分子量 | 261.23014 |
EINECS号 | |
相关类别 | |
Mol文件 | 287194-38-1.mol |
结构式 | ![]() |
287194-38-1 性质
储存条件 | Store at -20°C |
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溶解度 | 二甲基亚砜:≥32mg/mL(122.50mM) |
NF-κB
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DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibits TNF-a-induced NF-kB activation. (-)-DHMEQ is more potent and less toxic than DHMEQ racemate.
The antiarthritic effects of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) are examined on type-II collagen-induced arthritis in DBA1/J mice. This animal model is widely used for evaluation of antirheumatic drugs because of its pathological similarities to human rheumatoid arthritis. The arthritis is elicited and scored. (-)-DHMEQ markedly inhibits type-II-collagen-induced arthritis in mice, whereas DHMEQ racemate tends to only slightly inhibit it.