次苦参素
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- CAS号:
- 34981-25-4
- 英文名:
- Kuraridine
- 英文别名:
- Kuraridine;2,2',4,4'-Tetrahydroxy-6'-methoxy-3'-(5-methyl-2-isopropenylhex-4-enyl)chalcone;2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]phenyl]-3-(2,4-dihydroxyphenyl)-, (2E)-
- 中文名:
- 次苦参素
- 中文别名:
- 苦参啶;次苦参素;次苦参黄素
- CBNumber:
- CB83037362
- 分子式:
- C26H30O6
- 分子量:
- 438.51
- MOL File:
- 34981-25-4.mol
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次苦参素化学性质
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溶解度:
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Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
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形态:
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powder
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颜色:
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Yellow
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次苦参素性质、用途与生产工艺
Kuraridine 是一种从苦参根中得到的酮醇提取物。Kuraridine 对 cGMP 特异性磷酸二酯酶 5 型 (PDE5) 有抑制作用，IC50 值为 0.64 μM。
Kuraridine shows potent inhibitory activity (IC
50
=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively.Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal
I
GABA
induced by a saturating GABA concentration (1 mM).Kuraridine induces a concentration–response curves for
I
GABA
enhancement (EC
50
=4.0±2.4 μM) in
Xenopus
oocytes expressing GABA
A
receptors composed of α1, β2, and γ2S subunits.
次苦参素
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-121381 | Kuraridine | | 1 mg | 3500元 |
34981-25-4, 次苦参素 相关搜索:
- 标准品
- 标准品 -中药标准品
- 中药对照品
- 苦参啶
- 次苦参黄素
- 次苦参素
- 34981-25-4
- 2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]phenyl]-3-(2,4-dihydroxyphenyl)-, (2E)-
- 2,2',4,4'-Tetrahydroxy-6'-methoxy-3'-(5-methyl-2-isopropenylhex-4-enyl)chalcone
- Kuraridine