次苦参素
中文名称 | 次苦参素 |
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中文同义词 | 次苦参素;次苦参黄素;苦参啶 |
英文名称 | Kuraridine |
英文同义词 | Kuraridine;2,2',4,4'-Tetrahydroxy-6'-methoxy-3'-(5-methyl-2-isopropenylhex-4-enyl)chalcone;2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]phenyl]-3-(2,4-dihydroxyphenyl)-, (2E)- |
CAS号 | 34981-25-4 |
分子式 | C26H30O6 |
分子量 | 438.51 |
EINECS号 | 233-305-4 |
相关类别 | 中药对照品;标准品 -中药标准品;标准品 |
Mol文件 | 34981-25-4.mol |
结构式 |
次苦参素 性质
溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
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形态 | 粉末 |
颜色 | 粘黄色 |
PDE5 0.64 μM (IC 50 ) |
Kuraridine shows potent inhibitory activity (IC 50 =0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively.Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal I GABA induced by a saturating GABA concentration (1 mM).Kuraridine induces a concentration–response curves for I GABA enhancement (EC 50 =4.0±2.4 μM) in Xenopus oocytes expressing GABA A receptors composed of α1, β2, and γ2S subunits.