阿戈美拉汀杂质
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- CAS号:
- 166526-99-4
- 英文名:
- 3-Hydroxy Agomelatine
- 英文别名:
- 3-Hydroxyagomelatine;Agomelatine Impurity 37;Agomelatine 3-Hydroxy Impurity;N-[2-(7-methoxy-3-hydroxynaphth-1-yl)ethyl]-acetamide;N-(2-(3-Hydroxy-7-methoxynaphthalen-1-yl)ethyl)acetamide;Acetamide, N-[2-(3-hydroxy-7-methoxy-1-naphthalenyl)ethyl]-;Agomelatine impurity 1/3-Hydroxy Agomelatine/N-[2-(3-Hydroxy-7-methoxy-1-naphthalenyl)ethyl]acetamide
- 中文名:
- 阿戈美拉汀杂质
- 中文别名:
- 阿戈美拉汀杂质37;3-羟基阿戈美拉汀;阿戈美拉汀3-羟基杂质;化合物 3-HYDROXY AGOMELATINE
- CBNumber:
- CB83133666
- 分子式:
- C15H17NO3
- 分子量:
- 259.3
- MOL File:
- 166526-99-4.mol
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阿戈美拉汀杂质化学性质
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沸点:
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545.8±40.0 °C(Predicted)
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密度:
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1.190±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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9.85±0.40(Predicted)
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形态:
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Solid
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颜色:
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Off-white to light brown
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阿戈美拉汀杂质性质、用途与生产工艺
3-Hydroxy agomelatine 是 Agomelatine 的代谢产物。3-Hydroxy agomelatine 是 5-HT2C 受体拮抗剂,IC50 为 3.2 μM,Ki 为 1.8 μM。
5-HT
2C
Receptor
3.2 μM (IC
50
)
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5-HT
2C
Receptor
1.8 μM (Ki)
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Agomelatine and S 21517 have moderately high affinities for 5-HT
2C
receptors (
K
i
= 0.21 μM and 0.13 μM, respectively). The metabolite 3-Hydroxy agomelatine (S 21540) has a 10-fold lower affinity (
K
i
= 1.8 μM). Agomelatine, S 21517 and 3-Hydroxy agomelatine (10
-7
-10
-4
M) are antagonists at 5-HT
2C
receptors, with a rank order of efficacy as follows: S 21517>Agomelatine>3-Hydroxy agomelatine.
Increasing doses (from 1.25 to 40 mg/kg, intraperitoneal injection) of 3-Hydroxy agomelatine (S 21540) does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat.
阿戈美拉汀杂质
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-133111 | 3-羟基阿戈美拉汀D3 3-Hydroxy agomelatine | 166526-99-4 | 5mg | 1700元 |
2024/08/19 | HY-133111 | 3-Hydroxy agomelatine | | 10 mM * 1 mLin DMSO | 1870元 |
166526-99-4, 阿戈美拉汀杂质 相关搜索:
- 抑制剂
- 杂质对照品
- 化合物 3-HYDROXY AGOMELATINE
- 阿戈美拉汀3-羟基杂质
- 阿戈美拉汀杂质37
- 3-羟基阿戈美拉汀
- 166526-99-4
- 3-Hydroxyagomelatine
- N-[2-(7-methoxy-3-hydroxynaphth-1-yl)ethyl]-acetamide
- Agomelatine impurity 1/3-Hydroxy Agomelatine/N-[2-(3-Hydroxy-7-methoxy-1-naphthalenyl)ethyl]acetamide
- Agomelatine 3-Hydroxy Impurity
- Agomelatine Impurity 37
- Acetamide, N-[2-(3-hydroxy-7-methoxy-1-naphthalenyl)ethyl]-
- N-(2-(3-Hydroxy-7-methoxynaphthalen-1-yl)ethyl)acetamide