440662-09-9
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- CAS号:
- 440662-09-9
- 英文名:
- CeMMEC1
- 英文别名:
- CeMMEC1;cemmecl;CeMMEC1(free base);Epigenetic Reader Domain,CeMMEC-1,Inhibitor,DNA/RNA Synthesis,CeMMEC1,inhibit,CeMMEC 1;N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide;4-Isoquinolinecarboxamide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-;N-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide
- 中文名:
- 440662-09-9
- 中文别名:
- 化合物CEMMEC1;N-(2,3-二氢苯并[B][1,4]二噁烷-6-基)-2-甲基-1-氧代-1,2-二氢异喹啉-4-甲酰胺
- CBNumber:
- CB83171705
- 分子式:
- C19H16N2O4
- 分子量:
- 336.34
- MOL File:
- 440662-09-9.mol
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440662-09-9化学性质
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沸点:
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590.1±50.0 °C(Predicted)
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密度:
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1.386±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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11.38±0.20(Predicted)
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颜色:
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White to off-white
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440662-09-9性质、用途与生产工艺
CeMMEC1 是 BRD4 的抑制剂，同时对 TAF1 有很高的亲和性，对 TAF1 的 IC50 值为 0.9 μM，对 TAF1 (2) 的 Kd 值为 1.8 μM。
Kd: 1.8 μM (TAF1 (2))
IC50: 0.9 μM (TAF1)
CeMMEC1 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC
50
of 0.9 μM for TAF1, and a K
d
of 1.8 μM for TAF1 (2) and slso shows high affinity for the bromodomains of CREBBP, EP300, BRD9. CeMMEC1 (1, 10, 20 μM) decreases the number of THP1 cells in S phase in a dose manner. CeMMEC1 also induces apoptosis. CeMMEC1 in combination with (S)-JQ1 displays potently impaired cell viability than treatment alone.
440662-09-9
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-111445 | 440662-09-9
CeMMEC1 | 440662-09-9 | 5mg | 600元 |
| 2024/11/08 | HY-111445 | 440662-09-9
CeMMEC1 | 440662-09-9 | 10 mM * 1 mLin DMSO | 660元 |
440662-09-9, 440662-09-9 相关搜索:
- 抑制剂
- 天然产物
- N-(2,3-二氢苯并[B][1,4]二噁烷-6-基)-2-甲基-1-氧代-1,2-二氢异喹啉-4-甲酰胺
- 化合物CEMMEC1
- 440662-09-9
- N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide
- N-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide
- Epigenetic Reader Domain,CeMMEC-1,Inhibitor,DNA/RNA Synthesis,CeMMEC1,inhibit,CeMMEC 1
- cemmecl
- CeMMEC1(free base)
- 4-Isoquinolinecarboxamide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-
- CeMMEC1