AURORA INHIBITOR 1
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- CAS号:
- 2227019-45-4
- 英文名:
- Aurora inhibitor 1
- 英文别名:
- Aurora inhibitor 1;Imidazo[1,2-a]pyrazin-8-amine, N-[3-[[(1,1-dimethylethyl)amino]-2-pyridinylmethyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)-
- 中文名:
- AURORA INHIBITOR 1
- 中文别名:
- 化合物 T10412
- CBNumber:
- CB84844497
- 分子式:
- C23H25N9S
- 分子量:
- 459.58
- MOL File:
- 2227019-45-4.mol
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AURORA INHIBITOR 1化学性质
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密度:
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1.41±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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12.67±0.50(Predicted)
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AURORA INHIBITOR 1性质、用途与生产工艺
Aurora inhibitor 1 是一种有效的 Aurora 抑制剂,抑制 Aurora A 和 Aurora B 激酶的 IC50 分别 ≤4 nM 和 ≤13 nM。
Aurora A
4 nM (IC
50
)
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Aurora B
13 nM (IC
50
)
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Aurora inhibitor 1 (Compound 16) exhibits K
d
values of 0.01 nM for both Aurora A and Aurora B kinase.
Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally.
AURORA INHIBITOR 1
上下游产品信息
上游原料
下游产品
2227019-45-4, AURORA INHIBITOR 1 相关搜索:
- 对照品
- 化合物 T10412
- 2227019-45-4
- Imidazo[1,2-a]pyrazin-8-amine, N-[3-[[(1,1-dimethylethyl)amino]-2-pyridinylmethyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)-
- Aurora inhibitor 1