AURORA INHIBITOR 1
中文名称 | AURORA INHIBITOR 1 |
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中文同义词 | 化合物 T10412 |
英文名称 | Aurora inhibitor 1 |
英文同义词 | Aurora inhibitor 1;Imidazo[1,2-a]pyrazin-8-amine, N-[3-[[(1,1-dimethylethyl)amino]-2-pyridinylmethyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)- |
CAS号 | 2227019-45-4 |
分子式 | C23H25N9S |
分子量 | 459.58 |
EINECS号 | |
相关类别 | 对照品 |
Mol文件 | 2227019-45-4.mol |
结构式 |
AURORA INHIBITOR 1 性质
密度 | 1.41±0.1 g/cm3(Predicted) |
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酸度系数(pKa) | 12.67±0.50(Predicted) |
Aurora A 4 nM (IC 50 ) |
Aurora B 13 nM (IC 50 ) |
Aurora inhibitor 1 (Compound 16) exhibits K d values of 0.01 nM for both Aurora A and Aurora B kinase.
Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally.