化合物 T30600
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- CAS号:
- 2349356-09-6
- 英文名:
- BSJ-03-204
- 英文别名:
- BSJ-03-204;Acetamide, N-[4-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
- 中文名:
- 化合物 T30600
- 中文别名:
- 化合物 T30600;N-[4-[4-[6-[(6-乙酰基-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶基]-1-哌嗪基]丁基]-2-[[2-(2,6-二氧代-3-哌啶基)-2,3-二氢-1,3-二氧代-1H-异吲哚-4-基]氧基]乙酰胺
- CBNumber:
- CB85985157
- 分子式:
- C43H48N10O8
- 分子量:
- 832.9
- MOL File:
- 2349356-09-6.mol
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化合物 T30600化学性质
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密度:
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1.397±0.06 g/cm3(Predicted)
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储存条件:
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-20°C, protect from light
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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10.68±0.40(Predicted)
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颜色:
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Light yellow to green yellow
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化合物 T30600性质、用途与生产工艺
BSJ-03-204 是一种有效的，选择性的基于 Palbociclib (HY-50767) 的 CDK4/6 双重降解剂 (PROTAC)，对 CDK4/D1 和 CDK6/D1 的 IC50 分别为 26.9 nM 和 10.4 nM。BSJ-03-204 不诱导 IKZF1/3 降解，具有抗癌活性。
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CDK4/D1
26.9 nM (IC
50
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CDK6/D1
10.4 nM (IC
50
)
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BSJ-03-204 (0.0001-100 μM; for 3 or 4 days) has potent anti-proliferative effects on MCL cell lines.
BSJ-03-204 (1 μM; for 1 day) potently induces a G1 arrest.
BSJ-03-204 (0.1-5 μM; for 4 hours) only resultes in degradation of CDK4/6 in WT cells, not IKZF1/3.
Cell Proliferation Assay
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Cell Line:
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MCL cell lines (Jeko-1, Mino, Granta-519, Rec-1, and Maver-1 cells)
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Concentration:
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0.0001-100 μM
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Incubation Time:
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For 3 or 4 days
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Result:
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Had potent anti-proliferative effects on mantle cell lymphoma (MCL) cell lines.
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Cell Cycle Analysis
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Cell Line:
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Granta-519 cells
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Concentration:
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1 μM
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Incubation Time:
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For 1 day
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Result:
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Potently induced a G1 arrest.
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Western Blot Analysis
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Cell Line:
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Wildtype (WT) or Crbn
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Jurkat cells
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Concentration:
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0.1, 0.5, 1, 5 μM
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Incubation Time:
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For 4 hours
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Result:
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Only resulted in degradation of CDK4/6 in WT cells, not IKZF1/3.
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化合物 T30600
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-136250 | BSJ-03-204 | | 1 mg | 1591元 |
| 2024/04/30 | HY-136250 | 化合物 T30600
BSJ-03-204 | 2349356-09-6 | 5mg | 3500元 |
2349356-09-6, 化合物 T30600 相关搜索:
- C43H48N10O8
- N-[4-[4-[6-[(6-乙酰基-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶基]-1-哌嗪基]丁基]-2-[[2-(2,6-二氧代-3-哌啶基)-2,3-二氢-1,3-二氧代-1H-异吲哚-4-基]氧基]乙酰胺
- 化合物 T30600
- 2349356-09-6
- Acetamide, N-[4-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
- BSJ-03-204