PREGNENOLONE MONOSULFATE SODIUM SALT
|
|
- CAS号:
- 1852-38-6
- 英文名:
- PREGNENOLONE SULFATE SODIUM SALT
- 英文别名:
- Pregnenolone 3-Sulfate;PREGNENOLONE SULFATE SODIUM;Pregnenolone-3-sulfate Sodium;SodiuM Pregnenolone-d4 Sulfate;5-Pregnen-3β-ol-20-one sulfate;Pregnenolone sulphate Na+ salt;PREGNENOLONE SULFATE SODIUM SALT;PREGNENOLONE SULPHATE, SODIUM SALT;Pregnenolone-3-sulfate SodiuM Salt;3-Hydroxypregn-5-en-20-one sulfate
- 中文名:
- PREGNENOLONE MONOSULFATE SODIUM SALT
- 中文别名:
- 孕烯醇酮 硫酸钠盐;未标记的孕烯醇硫酸盐;化合物 T16574;孕烯醇硫酸盐 (20,21-13C2,99%
- CBNumber:
- CB8701970
- 分子式:
- C21H31NaO5S
- 分子量:
- 418.52
- MOL File:
- 1852-38-6.mol
|
|
|
PREGNENOLONE MONOSULFATE SODIUM SALT化学性质
-
熔点:
-
192 °C(lit.)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
methanol and water: 1.93 mg/mL
-
|
-
形态:
-
A crystalline solid
-
|
-
颜色:
-
White to off-white
-
|
PREGNENOLONE MONOSULFATE SODIUM SALT性质、用途与生产工艺
Pregnenolone monosulfate sodium salt (3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt) 是一种功能强大的神经甾体,是包括甾体酮在内的各种甾体激素的主要前体。Pregnenolone monosulfate sodium salt 是大麻素 CB1 受体的信号传导特异性抑制剂,抑制由 CB1 受体介导的四氢大麻酚 (THC) 的作用。Pregnenolone monosulfate sodium salt 可以保护大脑免受大麻毒性的侵袭。
CB1
|
Human Endogenous Metabolite
|
CB1 receptor stimulation increases brain Pregnenolone levels, which in turn exerts a negative feedback on the activity of the CB1 receptor antagonizing most of the known behavioral and somatic effects of THC. Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy.
The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC).
Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors
per se
. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule.
PREGNENOLONE MONOSULFATE SODIUM SALT
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-110189 | PREGNENOLONE MONOSULFATE SODIUM SALT Pregnenolone monosulfate sodium salt | 1852-38-6 | 5mg | 550元 |
2024/08/19 | HY-110189 | PREGNENOLONE MONOSULFATE SODIUM SALT Pregnenolone monosulfate sodium salt | 1852-38-6 | 10mg | 880元 |
PREGNENOLONE MONOSULFATE SODIUM SALT
生产厂家
1852-38-6, PREGNENOLONE MONOSULFATE SODIUM SALT 相关搜索:
Pregnenolone-[20,21-13C2,16,16-d2]sulfatesodiumsalt(Solution) 金刚石粉 Pregnanolone-[d5] Pregnenolone-[20,21-13C2,16,16-D2]sulfatesodiumsalt SodiumPregnenolone-17α,21,21,21-d4Sulfate 妊娠烯醇酮-D4 Pregnenolone-2,2,4,4-d4 Pregnenolone-[20,21-13C2,16,16-D2] 孕烯醇酮甲醚-[D4] Pregnenolone-[20,21-13C2,16,16-d2] 孕烯醇酮
- Steroids
- Ligand-Gated Ion Channels
- Ion Channels
- GABA and Glycine Receptor Modulators
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- C21H31O5SNa
- C21H31NaO5S
- 化合物 T16574
- 孕烯醇硫酸盐 (20,21-13C2,99%
- 未标记的孕烯醇硫酸盐
- 孕烯醇酮 硫酸钠盐
- 1852-38-6
- 5-PREGNEN-3β-OL-20-ONE SULPHATE, SODIUM SALT
- 3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt
- Pregnenolone-3-sulfate Sodium
- Pregnenolone 3-Sulfate
- 3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt
- Pregnenolone sulphate Na+ salt
- (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt
- Pregnenolone monosulfate sodium salt
- 5-Pregnen-3β-ol-20-one sulfate
- 3β-Hydroxy-5-pregnen-20-one 3-sulfate
- 3-Hydroxypregn-5-en-20-one sulfate
- Pregnenolone-3-sulfate SodiuM Salt
- SodiuM Pregnenolone-d4 Sulfate
- 3β-Hydroxy-5-pregnen-20-one 3-sulfate, 3-Hydroxypregn-5-en-20-one sulfate, 5-Pregnen-3β-ol-20-one sulfate
- 5-Pregnen-3-beta-ol-2o-one sulphate,sodium salt
- PREGNENOLONE SULFATE SODIUM SALT 5-PREGN EN-3B-OL-20-ON
- 5-pregnen-3B-ol-20-one sulfate sodium
- 5-PREGNEN-3BETA-OL-20-ONE3-SULFATE SODIUM
- 5-PREGNEN-3B-OL-20-ONE SULFATE SODIUM SALT
- 5-PREGNEN-3-BETA-OL-20-ONE SULPHATE, SODIUM SALT
- 5-PREGNEN-3BETA-OL-20-ONE SULFATE SODIUM SALT
- 3-HYDROXYPREGN-5-EN-20-ONE SULFATE SODIUM SALT
- 3-BETA-HYDROXY-5-PREGNEN-20-ONE 3-SULPHATE, SODIUM SALT
- 3B-HYDROXY-5-PREGNEN-20-ONE 3-SULFATE SODIUM SALT
- PREGNENOLONE SULPHATE, SODIUM SALT
- PREGNENOLONE SULFATE SODIUM SALT
- PREGNENOLONE SULFATE SODIUM