PREGNENOLONE MONOSULFATE SODIUM SALT
中文名称 | PREGNENOLONE MONOSULFATE SODIUM SALT |
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中文同义词 | 孕烯醇酮 硫酸钠盐;未标记的孕烯醇硫酸盐;孕烯醇硫酸盐 (20,21-13C2,99%;化合物 T16574 |
英文名称 | PREGNENOLONE SULFATE SODIUM SALT |
英文同义词 | PREGNENOLONE SULFATE SODIUM;PREGNENOLONE SULFATE SODIUM SALT;PREGNENOLONE SULPHATE, SODIUM SALT;3B-HYDROXY-5-PREGNEN-20-ONE 3-SULFATE SODIUM SALT;3-BETA-HYDROXY-5-PREGNEN-20-ONE 3-SULPHATE, SODIUM SALT;3-HYDROXYPREGN-5-EN-20-ONE SULFATE SODIUM SALT;5-PREGNEN-3BETA-OL-20-ONE SULFATE SODIUM SALT;5-PREGNEN-3-BETA-OL-20-ONE SULPHATE, SODIUM SALT |
CAS号 | 1852-38-6 |
分子式 | C21H31NaO5S |
分子量 | 418.52 |
EINECS号 | |
相关类别 | Steroids |
Mol文件 | 1852-38-6.mol |
结构式 |
PREGNENOLONE MONOSULFATE SODIUM SALT 性质
熔点 | 192 °C(lit.) |
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储存条件 | Store at -20°C |
溶解度 | 溶于甲醇和水的混溶液中,1.93mg/mL |
形态 | 结晶固体 |
颜色 | 白色至米白色 |
CB1
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Human Endogenous Metabolite
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CB1 receptor stimulation increases brain Pregnenolone levels, which in turn exerts a negative feedback on the activity of the CB1 receptor antagonizing most of the known behavioral and somatic effects of THC. Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy.
The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC).
Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se . Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule.
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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