ZATEBRADINE HCL
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- CAS号:
- 91940-87-3
- 英文名:
- 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE
- 英文别名:
- UL-FS49;ULFS 49CL;Zatebradine HCl;ZATEBRADINE HYDROCHLORIDE;Zatebradine HCl (UL-FS-49;Zatebradine dihydrochloride;3-(3-((3,4-dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride;3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE;3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE;7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
- 中文名:
- ZATEBRADINE HCL
- 中文别名:
- 盐酸扎替雷定;化合物 T13387L;ZATEBRADINE盐酸盐
- CBNumber:
- CB8727004
- 分子式:
- C26H37ClN2O5
- 分子量:
- 493.04
- MOL File:
- 91940-87-3.mol
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ZATEBRADINE HCL化学性质
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熔点:
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188° and mp 168°
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储存条件:
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2-8°C
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溶解度:
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H2O: ~14 mg/mL
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形态:
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solid
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颜色:
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white
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水溶解性:
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Soluble in water (100mM)
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ZATEBRADINE HCL性质、用途与生产工艺
Zatebradine (UL-FS-49 (free base)) 是一种高效的 HCN Channel 抑制剂,其 IC50 值为 1.96 µM。Zatebradine 会阻止通过人类 HCN1,HCN2,HCN3 和 HCN4 通道的缓慢内向电流,其 IC50 值分别为 1.83 µM,2.21 µM,1.90 µM 和 1.88 µM。
IC50: 1.96 µM (
HCN channels
)
The use-dependent blockade by Zatebradine of the cardiac pacemaker current from rabbit sino-atrial node cells has an apparent
K
d
of 480 nM.
Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes; male C57/Bl6-mice) reduces the heart rate dose-dependently from 600 to 200 bpm with
ED
50
value of 1.8 mg/kg and induces increasing arrhythmia.
Animal Model:
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Male C57/Bl6-mice
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Dosage:
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0 mg/kg, 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
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Administration:
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Intraperitoneal injection; for 30 minutes
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Result:
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Observed acute blood glucose reduction, dose-dependently reduced glycated hemoglobin, significantly prevented the decrease of IRI levels at doses of 3 and 10 mg/kg, and no difference in food intake or body weight.
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ZATEBRADINE HCL
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-13422 | Zatebradine hydrochloride | | 1 mg | 396元 |
2024/04/30 | HY-13422 | ZATEBRADINE HCL Zatebradine hydrochloride | 91940-87-3 | 5mg | 990元 |
91940-87-3, ZATEBRADINE HCL 相关搜索:
- Ion transporter and other ion channel
- 药靶配体
- C26H37ClN2O5
- C26H36N2O5HCl
- ZATEBRADINE盐酸盐
- 化合物 T13387L
- 盐酸扎替雷定
- 91940-87-3
- 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE
- Zatebradine HCl (UL-FS-49
- 3-(3-((3,4-dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride
- 7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
- Zatebradine dihydrochloride
- ULFS 49CL
- Zatebradine HCl
- 2H-3-Benzazepin-2-one, 3-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride
- 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE
- UL-FS49, 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
- ZATEBRADINE HYDROCHLORIDE
- UL-FS49