6RK73
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- CAS号:
- 1895050-66-4
- 英文名:
- 6RK73
- 英文别名:
- 6RK73;6RK-73,6RK73;3-Pyrrolidinecarboxamide, 1-cyano-N-[5-(4-morpholinyl)-2-thiazolyl]-, (3S)-
- 中文名:
- 6RK73
- 中文别名:
- 化合物6RK73;化合物 T10188
- CBNumber:
- CB88054296
- 分子式:
- C13H17N5O2S
- 分子量:
- 307.37
- MOL File:
- 1895050-66-4.mol
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6RK73化学性质
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密度:
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1.41±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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8.04±0.70(Predicted)
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颜色:
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Off-white to light yellow
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6RK73性质、用途与生产工艺
6RK73 是一种共价不可逆的特异性 UCHL1 抑制剂,IC50 为 0.23 µM。6RK73 对 UCHL3 几乎没有抑制效果 (IC50=236 µM)。6RK73 特异性抑制乳腺癌中 UCHL1 的活性。
IC50: 0.23 µM (UCHL1), 236 µM (UCHL3)
6RK73 (5 µM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells.
6RK73(5 µM; 24-48 hours) results migration significantly slower than the DMSO control group in MDA-MB-436 cells.
Cell Viability Assay
Cell Line:
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MDA-MB-436 cells
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Concentration:
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5 µM
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Incubation Time:
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24, 48 hours
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Result:
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Migrated significantly slower than the DMSO control group
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Western Blot Analysis
Cell Line:
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MDA-MB-436 cells
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Concentration:
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5 µM
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Incubation Time:
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1, 2, 3 hours
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Result:
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Displayed strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels.
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6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish.
6RK73
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-133118 | 6RK73 | | 1 mg | 1447元 |
2024/04/30 | HY-133118 | 6RK73 6RK73 | 1895050-66-4 | 10mM * 1mLin DMSO | 4180元 |
1895050-66-4, 6RK73 相关搜索:
- 制剂-抑制剂
- 化合物6RK73
- 化合物 T10188
- 1895050-66-4
- 3-Pyrrolidinecarboxamide, 1-cyano-N-[5-(4-morpholinyl)-2-thiazolyl]-, (3S)-
- 6RK-73,6RK73
- 6RK73