6RK73
| 中文名称 | 6RK73 |
|---|---|
| 中文同义词 | 化合物 T10188;化合物6RK73 |
| 英文名称 | 6RK73 |
| 英文同义词 | 6RK73;6RK-73,6RK73;3-Pyrrolidinecarboxamide, 1-cyano-N-[5-(4-morpholinyl)-2-thiazolyl]-, (3S)- |
| CAS号 | 1895050-66-4 |
| 分子式 | C13H17N5O2S |
| 分子量 | 307.37 |
| EINECS号 | |
| 相关类别 | 制剂-抑制剂 |
| Mol文件 | 1895050-66-4.mol |
| 结构式 |  |
6RK73 性质
| 密度 | 1.41±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.04±0.70(Predicted) |
| 颜色 | 米白色至浅黄色 |
6RK73 是一种共价不可逆的特异性 UCHL1 抑制剂，IC50 为 0.23 µM。6RK73 对 UCHL3 几乎没有抑制效果 (IC50=236 µM)。6RK73 特异性抑制乳腺癌中 UCHL1 的活性。
IC50: 0.23 µM (UCHL1), 236 µM (UCHL3)
6RK73 (5 µM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells.
6RK73(5 µM; 24-48 hours) results migration significantly slower than the DMSO control group in MDA-MB-436 cells.
Cell Viability Assay
| Cell Line: | MDA-MB-436 cells |
| Concentration: | 5 µM |
| Incubation Time: | 24, 48 hours |
| Result: | Migrated significantly slower than the DMSO control group |
Western Blot Analysis
| Cell Line: | MDA-MB-436 cells |
| Concentration: | 5 µM |
| Incubation Time: | 1, 2, 3 hours |
| Result: | Displayed strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels. |
6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-133118 | 6RK73 | 1 mg | 1447元 | |
| 2024/04/30 | HY-133118 | 6RK73 6RK73 | 1895050-66-4 | 10mM * 1mLin DMSO | 4180元 |