网站主页 >> CAS数据库列表 >> L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-
L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-
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- CAS号:
- 1941174-13-5
- 英文名:
- L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-
- 英文别名:
- KMH-233;L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-
- 中文名:
- L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-
- 中文别名:
- 化合物 T32404
- CBNumber:
- CB88118963
- 分子式:
- C32H25N7O5
- 分子量:
- 587.58
- MOL File:
- 1941174-13-5.mol
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L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-化学性质
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密度:
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1.41±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 100 mg/mL (170.19 mM)
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酸度系数(pKa):
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2.16±0.10(Predicted)
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形态:
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Solid
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颜色:
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White to yellow
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L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-性质、用途与生产工艺
KMH-233 是一种有效,可逆的且选择性的 l 型氨基酸转运蛋白 1 (LAT1) 抑制剂,可抑制LAT1底物,l-leucin 的摄取 (IC50=18 μM) 以及细胞生长。即使在低浓度 (25 μM) 下,KMH-233 仍可显着增强 Bestatin 和顺铂的疗效。
KMH-233 is able to inhibit binding and transport of essential neutral amino acids and thus, inhibit the cell growth of cancer cells.
KMH-233 shows a significant reduction of cell growth with an IC
50
of 124 µM.
KMH-233 is effective and able to potentiate the anti-proliferative efficacy of Bestatin (100 µM) and Cisplatin (100 µM) at a lower concentration of 25 µM, inhibiting cell growth 53% and 50%, respectively.
Cell Proliferation Assay
Cell Line:
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MCF-7 cells
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Concentration:
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0.5-1000 μM
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Incubation Time:
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72 hours
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Result:
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Showed a significant reduction of cell growth with an IC
50
of 124 µM.
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L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-120139 | KMH-233 | | 1 mg | 1600元 |
2024/04/30 | HY-120139 | L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]- KMH-233 | 1941174-13-5 | 5mg | 4800元 |
L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-
生产厂家
1941174-13-5, L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]- 相关搜索:
- C32H25N7O5
- 化合物 T32404
- 1941174-13-5
- KMH-233
- L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-