L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-
中文名称 | L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]- |
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中文同义词 | 化合物 T32404 |
英文名称 | L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]- |
英文同义词 | L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-;KMH-233 |
CAS号 | 1941174-13-5 |
分子式 | C32H25N7O5 |
分子量 | 587.58 |
EINECS号 | |
相关类别 | |
Mol文件 | 1941174-13-5.mol |
结构式 | ![]() |
L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]- 性质
密度 | 1.41±0.1 g/cm3(Predicted) |
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储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:100 mg/mL(170.19 mM) |
酸度系数(pKa) | 2.16±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至黄色 |
L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]- 用途与合成方法
KMH-233 is able to inhibit binding and transport of essential neutral amino acids and thus, inhibit the cell growth of cancer cells.
KMH-233 shows a significant reduction of cell growth with an IC
50
of 124 µM.
KMH-233 is effective and able to potentiate the anti-proliferative efficacy of Bestatin (100 µM) and Cisplatin (100 µM) at a lower concentration of 25 µM, inhibiting cell growth 53% and 50%, respectively.
Cell Proliferation Assay
Cell Line: | MCF-7 cells |
Concentration: | 0.5-1000 μM |
Incubation Time: | 72 hours |
Result: | Showed a significant reduction of cell growth with an IC 50 of 124 µM. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-120139 | KMH-233 | 1 mg | 1600元 | |
2024/08/19 | HY-120139 | L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]- KMH-233 | 1941174-13-5 | 5mg | 4800元 |