CGS 9343B
|
|
|
- CAS号:
- 109826-27-9
- 英文名:
- CGS 9343B
- 英文别名:
- KW-5617;Zy-17617B;CGS 9343B;Zaldaride maleate;Zaldaride·maleic acid;1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-onemaleate
- 中文名:
- CGS 9343B
- 中文别名:
- 化合物 T17282
- CBNumber:
- CB8826475
- 分子式:
- C26H28N4O2.C4H4O4
- 分子量:
- 544.605
- MOL File:
- 109826-27-9.mol
|
|
|
CGS 9343B化学性质
-
熔点:
-
189-190°
-
|
-
储存条件:
-
Desiccate at RT
-
|
-
溶解度:
-
DMSO: >10mg/mL
-
|
-
形态:
-
powder
-
|
-
颜色:
-
white to off-white
-
|
CGS 9343B性质、用途与生产工艺
Zaldaride maleate (CGS-9343B) 是一个有效的、有口服活性的、选择性的钙调蛋白 (calmodulin) 的抑制剂，可抑制钙调蛋白刺激cAMP磷酸二酯酶的活性，IC50 值为 3.3 nM。Zaldaride maleate (CGS-9343B) 可抑制雌激素诱导的 ER 转录激活，可逆地阻断 PC12 细胞中电压激活的的 Na+、Ca2+和 K+电流，抑制 nAChR。
IC50: 3.3 nM (calmodulin).
Zaldaride maleate (KW 5617, P.O., 3 mg/kg) ameliorates the diarrhea in the 16, 16-dimethyl prostaglandin E
2
model.
|
Animal Model:
|
Male Sprague-dawley rats neighing 193-265 g.
|
|
Dosage:
|
3-100 mg/kg.
|
|
Administration:
|
P.O..
|
|
Result:
|
KW-5617 at 3 to100 mg/kg 60 min before DMPGE2 challenge, significantly ameliorated the DMPGE-induced diarrhea, when this drug at 100 mg/kg (p.o. significantly reduced fecaevacuation.
Pretreatment with KW-5617 at 3 to 10 mg/kg (p.o.) significantly delayed the onset of diarrhea, and this drug at 30 and 100 mg/kg (p.o. ) reduced or abolished the incidence of diarrhea.
|
CGS 9343B
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-105118A | Zaldaride maleate | | 1 mg | 2080元 |
| 2024/08/19 | HY-105118A | CGS 9343B
Zaldaride maleate | 109826-27-9 | 5mg | 5200元 |
109826-27-9, CGS 9343B 相关搜索:
- C26H28N4O2C4H4O4
- 化合物 T17282
- 109826-27-9
- Zaldaride maleate
- KW-5617
- 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-onemaleate
- Zy-17617B
- Zaldaride·maleic acid
- CGS 9343B