BSH-IN-1
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- CAS号:
- 2553217-91-5
- 英文名:
- BSH-IN-1
- 英文别名:
- BSH-IN-1;BSH IN 1,BSHIN1;26,27-Dinorcholestan-24-one, 25-fluoro-3,7-dihydroxy-, (3α,5β,7α)-
- 中文名:
- BSH-IN-1
- 中文别名:
- 化合物 T10623;化合物BSH-IN-1
- CBNumber:
- CB89041464
- 分子式:
- C25H41FO3
- 分子量:
- 408.6
- MOL File:
- 2553217-91-5.mol
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BSH-IN-1化学性质
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沸点:
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523.9±30.0 °C(Predicted)
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密度:
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1.097±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 10 mM
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形态:
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A solid
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酸度系数(pKa):
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14.79±0.70(Predicted)
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颜色:
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White to yellow
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BSH-IN-1性质、用途与生产工艺
BSH-IN-1 是一种重组的肠道细菌胆汁盐水解酶 (BSHs) 的有效和共价抑制剂，对 B. longum BSH (革兰氏阳性) 和 B. theta BSH (革兰氏阴性菌) 的 IC50 分别为 108 和 427 nM。
BSH-IN-1 (Compound 7) also inhibits BSH activity in growing cultures of Gram-negative (
B. theta
VPI-5482,
Bacteroides fragilis
ATCC 25285, and
Bacteroides vulgatus
ATCC 8482) and Gram-positive (
Lactobacillus plantarum
WCFS1,
C. perfringens
ATCC 13124, and
Bifidobacterium adolescentis
L2-32) bacteria. BSH-IN-1 (Compound 7) also is a potent BSH inhibitor in growing bacterial cultures with IC
50
s of 237 nM and 1070 nM for
B. adolescentis
(Gram positive) and
B. theta
(Gram negative), respectively.
BSH-IN-1 (Compound 7; 10 mg/kg; a single dose; gavage) inhibits BSH activity in C57BL/6 mice and can be gut-restricted.
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Animal Model:
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C57BL/6 mice
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Dosage:
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10 mg/kg
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Administration:
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Single gavage
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Result:
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Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community.
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BSH-IN-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-135659 | BSH-IN-1 | | 1 mg | 1580元 |
| 2024/08/19 | HY-135659 | BSH-IN-1
BSH-IN-1 | 2553217-91-5 | 5mg | 3950元 |
2553217-91-5, BSH-IN-1 相关搜索:
- 制剂-抑制剂
- 化合物BSH-IN-1
- 化合物 T10623
- 2553217-91-5
- 26,27-Dinorcholestan-24-one, 25-fluoro-3,7-dihydroxy-, (3α,5β,7α)-
- BSH IN 1,BSHIN1
- BSH-IN-1