BSH-IN-1
| 中文名称 | BSH-IN-1 |
|---|---|
| 中文同义词 | 化合物 T10623;化合物BSH-IN-1 |
| 英文名称 | BSH-IN-1 |
| 英文同义词 | BSH-IN-1;BSH IN 1,BSHIN1;26,27-Dinorcholestan-24-one, 25-fluoro-3,7-dihydroxy-, (3α,5β,7α)- |
| CAS号 | 2553217-91-5 |
| 分子式 | C25H41FO3 |
| 分子量 | 408.6 |
| EINECS号 | |
| 相关类别 | 制剂-抑制剂 |
| Mol文件 | 2553217-91-5.mol |
| 结构式 |  |
BSH-IN-1 性质
| 沸点 | 523.9±30.0 °C(Predicted) |
|---|---|
| 密度 | 1.097±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：10mM |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.79±0.70(Predicted) |
| 颜色 | 白色至黄色 |
BSH-IN-1 (Compound 7) also inhibits BSH activity in growing cultures of Gram-negative ( B. theta VPI-5482, Bacteroides fragilis ATCC 25285, and Bacteroides vulgatus ATCC 8482) and Gram-positive ( Lactobacillus plantarum WCFS1, C. perfringens ATCC 13124, and Bifidobacterium adolescentis L2-32) bacteria. BSH-IN-1 (Compound 7) also is a potent BSH inhibitor in growing bacterial cultures with IC 50 s of 237 nM and 1070 nM for B. adolescentis (Gram positive) and B. theta (Gram negative), respectively.
BSH-IN-1 (Compound 7; 10 mg/kg; a single dose; gavage) inhibits BSH activity in C57BL/6 mice and can be gut-restricted.
| Animal Model: | C57BL/6 mice |
| Dosage: | 10 mg/kg |
| Administration: | Single gavage |
| Result: | Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-135659 | BSH-IN-1 | 1 mg | 1920元 | |
| 2024/04/30 | HY-135659 | BSH-IN-1 BSH-IN-1 | 2553217-91-5 | 5mg | 4800元 |