KB 5492
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- CAS号:
- 129200-10-8
- 英文名:
- KB 5492
- 英文别名:
- KB 5492;KB-5492 anhydrous;KB 5492 anhydrous,KB5492 anhydrous
- 中文名:
- KB 5492
- 中文别名:
- 化合物 T24254;化合物 KB-5492 ANHYDROUS
- CBNumber:
- CB91395209
- 分子式:
- C27H34N2O10
- 分子量:
- 546.57
- MOL File:
- 129200-10-8.mol
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KB 5492化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (457.40 mM)
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形态:
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Solid
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颜色:
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White to off-white
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KB 5492性质、用途与生产工艺
KB-5492 anhydrous 是一种有效的和选择性的 sigma 受体抑制剂,抑制 [3H]1,3-di(2-tolyl)guanidine (DTG) 与 sigma 受体结合,IC50 值为 3.15 μM。KB-5492 anhydrous 是一种抗溃疡药。
IC50: 3.15 μM (sigma receptor)
KB-5492 (0.001-100 μM) inhibits specific [
3
H]DTG binding in a concentration-dependent manner.
KB-5492 (0.1-1 mM) significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in
51
Cr release from gastric epithelial cells.
KB-5492 (200 mg/kg; p.o.) prevents macroscopic lesions in the gastric mucosa.
Animal Model:
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Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage
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Dosage:
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200 mg/kg
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Administration:
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Oral gavage
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Result:
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Reduced the lesion length as compared with the control.
Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.
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KB 5492
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-19120 | KB-5492 anhydrous | | 1 mg | 1800元 |
2024/08/19 | HY-19120 | KB 5492 KB-5492 anhydrous | 129200-10-8 | 5mg | 4300元 |
129200-10-8, KB 5492 相关搜索:
- 抑制剂
- 化合物 KB-5492 ANHYDROUS
- 化合物 T24254
- 129200-10-8
- KB 5492 anhydrous,KB5492 anhydrous
- KB-5492 anhydrous
- KB 5492