160756-38-7
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- CAS号:
- 160756-38-7
- 英文名:
- CNS-5161 (hydrochloride)
- 英文别名:
- CNS 5161A;CNS-5161 (hydrochloride);CNS-5161 hydrochloride (CNS 5161A)
- 中文名:
- 160756-38-7
- 中文别名:
- 化合物 T10852;化合物CNS-5161盐酸盐
- CBNumber:
- CB93175533
- 分子式:
- C16H19Cl2N3S2
- 分子量:
- 388.37
- MOL File:
- 160756-38-7.mol
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160756-38-7化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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160756-38-7性质、用途与生产工艺
CNS-5161 hydrochloride 是一种新型 NMDA 离子通道拮抗剂，与 NMDA 受体/离子通道位点相互作用，产生对谷氨酸作用的非竞争性阻断。
NMDA receptor/ion channel
CNS-5161 (CNS 5161) is a novel and selective noncompetitive antagonist of the NMDA subset of glutamate receptors in the mammalian brain. CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [
3
H] MK-801 binding with a K
i
of 1.8 nM in synaptosomal membrane preparations from rat brain.
In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED
80
of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats.
160756-38-7
上下游产品信息
上游原料
下游产品
160756-38-7, 160756-38-7 相关搜索:
- 化合物CNS-5161盐酸盐
- 化合物 T10852
- 160756-38-7
- CNS-5161 hydrochloride (CNS 5161A)
- CNS 5161A
- CNS-5161 (hydrochloride)