160756-38-7
| 中文名称 | 160756-38-7 |
|---|---|
| 中文同义词 | 化合物 T10852;化合物CNS-5161盐酸盐 |
| 英文名称 | CNS-5161 (hydrochloride) |
| 英文同义词 | CNS-5161 (hydrochloride);CNS 5161A;CNS-5161 hydrochloride (CNS 5161A) |
| CAS号 | 160756-38-7 |
| 分子式 | C16H19Cl2N3S2 |
| 分子量 | 388.37 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 160756-38-7.mol |
| 结构式 |  |
160756-38-7 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
NMDA receptor/ion channel
CNS-5161 (CNS 5161) is a novel and selective noncompetitive antagonist of the NMDA subset of glutamate receptors in the mammalian brain. CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [ 3 H] MK-801 binding with a K i of 1.8 nM in synaptosomal membrane preparations from rat brain.
In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED 80 of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats.