143584-75-2
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- CAS号:
- 143584-75-2
- 英文名:
- S-methyl-KE-298
- 英文别名:
- -KE-298;S-methyl-KE-298;2-((Methylthio)methyl)-4-oxo-4-(p-tolyl)butanoic acid;Benzenebutanoic acid, 4-methyl-α-[(methylthio)methyl]-γ-oxo-;inhibit,M-2,Drug Metabolite,SmethylKE298,Matrix metalloproteinases,Inhibitor,S methyl KE 298,M 2,MMP
- 中文名:
- 143584-75-2
- 中文别名:
- S-甲基-KE-298;化合物S-METHYL-KE-298;2-((甲硫基)甲基)-4-氧代-4-(对甲苯基)丁酸
- CBNumber:
- CB93175588
- 分子式:
- C13H16O3S
- 分子量:
- 252.33
- MOL File:
- 143584-75-2.mol
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143584-75-2化学性质
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沸点:
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457.2±45.0 °C(Predicted)
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密度:
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1.188±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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4.11±0.23(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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143584-75-2性质、用途与生产工艺
S-methyl-KE-298 是 KE-298 的一种活性代谢物。KE-298 抑制类风湿关节炎 (RA) 滑膜细胞的基质金属蛋白酶 (MMP-1) 产生。
S-methyl-KE-298 is a methyl conjugate of deacetyl-KE-298 is plasma. In vitro protein binding of KE-298 and its plasma metabolites, deacetyl-KE-298 (M-1) and S-methyl-KE-298 (M-2), is high in rat (>97%), dog (>89%) and human plasma (>99%), respectively. KE-298 blocks this IL-1β-induced pro-MMP-2 activation and MT1-MMP expression, but does not affect IL-1β-induced tissue inhibitor of metalloproteinase-2 (TIMP-2) secretion from rheumatoid synovial cells. KE-298 inhibits MMP-1 production from rheumatoid arthritis (RA) synovial cells by affecting a transcription factor, AP-1. KE-298 inhibits the basal levels of MT1-MMP expression of unstimulated rheumatoid synovial cells.
143584-75-2
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2021/03/30 | S0300 | 143584-75-2
S-methyl-KE-298 | 143584-75-2 | 5mg | 3988.53元 |
| 2021/03/30 | S0300 | 143584-75-2
S-methyl-KE-298 | 143584-75-2 | 25mg | 12031.1元 |
143584-75-2, 143584-75-2 相关搜索:
- 药靶配体
- S-甲基-KE-298
- 2-((甲硫基)甲基)-4-氧代-4-(对甲苯基)丁酸
- 化合物S-METHYL-KE-298
- 143584-75-2
- 2-((Methylthio)methyl)-4-oxo-4-(p-tolyl)butanoic acid
- Benzenebutanoic acid, 4-methyl-α-[(methylthio)methyl]-γ-oxo-
- inhibit,M-2,Drug Metabolite,SmethylKE298,Matrix metalloproteinases,Inhibitor,S methyl KE 298,M 2,MMP
- -KE-298
- S-methyl-KE-298