143584-75-2
| 中文名称 | 143584-75-2 |
|---|---|
| 中文同义词 | 化合物S-METHYL-KE-298;2-((甲硫基)甲基)-4-氧代-4-(对甲苯基)丁酸;S-甲基-KE-298 |
| 英文名称 | S-methyl-KE-298 |
| 英文同义词 | S-methyl-KE-298;-KE-298;inhibit,M-2,Drug Metabolite,SmethylKE298,Matrix metalloproteinases,Inhibitor,S methyl KE 298,M 2,MMP;Benzenebutanoic acid, 4-methyl-α-[(methylthio)methyl]-γ-oxo-;2-((Methylthio)methyl)-4-oxo-4-(p-tolyl)butanoic acid |
| CAS号 | 143584-75-2 |
| 分子式 | C13H16O3S |
| 分子量 | 252.33 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 143584-75-2.mol |
| 结构式 |  |
143584-75-2 性质
| 沸点 | 457.2±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.188±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 4.11±0.23(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
S-methyl-KE-298 是 KE-298 的一种活性代谢物。KE-298 抑制类风湿关节炎 (RA) 滑膜细胞的基质金属蛋白酶 (MMP-1) 产生。
S-methyl-KE-298 is a methyl conjugate of deacetyl-KE-298 is plasma. In vitro protein binding of KE-298 and its plasma metabolites, deacetyl-KE-298 (M-1) and S-methyl-KE-298 (M-2), is high in rat (>97%), dog (>89%) and human plasma (>99%), respectively. KE-298 blocks this IL-1β-induced pro-MMP-2 activation and MT1-MMP expression, but does not affect IL-1β-induced tissue inhibitor of metalloproteinase-2 (TIMP-2) secretion from rheumatoid synovial cells. KE-298 inhibits MMP-1 production from rheumatoid arthritis (RA) synovial cells by affecting a transcription factor, AP-1. KE-298 inhibits the basal levels of MT1-MMP expression of unstimulated rheumatoid synovial cells.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2021/03/30 | S0300 | 143584-75-2 S-methyl-KE-298 | 143584-75-2 | 5mg | 3988.53元 |
| 2021/03/30 | S0300 | 143584-75-2 S-methyl-KE-298 | 143584-75-2 | 25mg | 12031.1元 |
上游原料