TCO-PEG12-NHS Ester
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- CAS号:
- 2185016-39-9
- 英文名:
- TCO-PEG12-NHS Ester
- 英文别名:
- TCO-PEG12-NHS Ester;(4E)-TCO-PEG12-NHS ester;5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azahentetracontanedioic acid, 1-(4E)-4-cycloocten-1-yl 41-(2,5-dioxo-1-pyrrolidinyl) ester
- 中文名:
- TCO-PEG12-NHS Ester
- 中文别名:
- 反式环辛烯-十二聚乙二醇-活性酯
- CBNumber:
- CB93345118
- 分子式:
- C40H70N2O18
- 分子量:
- 866.99
- MOL File:
- 2185016-39-9.mol
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TCO-PEG12-NHS Ester化学性质
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密度:
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1.20±0.1 g/cm3(Predicted)
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溶解度:
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Soluble in DMSO, DCM, DMF
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酸度系数(pKa):
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11.95±0.46(Predicted)
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形态:
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Liquid
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颜色:
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Colorless to light yellow
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TCO-PEG12-NHS Ester性质、用途与生产工艺
TCO-PEG12-NHS ester 是一种 PROTAC 连接桥，属于 PEG 类。TCO-PEG12-NHS ester 可用于合成一系列 PROTAC 分子。TCO-PEG12-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
TCO-PEG12-NHS Ester
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2185016-39-9, TCO-PEG12-NHS Ester 相关搜索:
- 反式环辛烯-十二聚乙二醇-活性酯
- 2185016-39-9
- (4E)-TCO-PEG12-NHS ester
- 5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azahentetracontanedioic acid, 1-(4E)-4-cycloocten-1-yl 41-(2,5-dioxo-1-pyrrolidinyl) ester
- TCO-PEG12-NHS Ester