TCO-PEG12-NHS Ester
- CAS No.
- 2185016-39-9
- Chemical Name:
- TCO-PEG12-NHS Ester
- Synonyms
- TCO-PEG12-NHS Ester;(4E)-TCO-PEG12-NHS ester;5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azahentetracontanedioic acid, 1-(4E)-4-cycloocten-1-yl 41-(2,5-dioxo-1-pyrrolidinyl) ester
- CBNumber:
- CB93345118
- Molecular Formula:
- C40H70N2O18
- Molecular Weight:
- 866.99
- MDL Number:
- MFCD30536161
- MOL File:
- 2185016-39-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
TCO-PEG12-NHS Ester Chemical Properties,Uses,Production
Description
TCO-PEG12-NHS Ester is a water soluble PEG linker containing a TCO moiety and a NHS ester. PEG12 linear arm increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.
Biological Activity
TCO-PEG12-NHS ester is a PROTAC bridge and belongs to the PEG class.It can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
|
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4824 | 58 |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 029-86217788 13892832556 | 2440688701@qq.com | China | 1992 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | malulu@leyan.com | China | 54986 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85563444 18351873721 | purchase@synzest.com | China | 10441 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 3001317055@qq.com | China | 9615 | 58 |
View Lastest Price from TCO-PEG12-NHS Ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-10 | (4E)-TCO-PEG12-NHS ester
2185016-39-9
|
US $0.00 / mg | 250mg | >95.00% | 250mg | Xian confluore Biological Technology Co., Ltd. |
-
- (4E)-TCO-PEG12-NHS ester
2185016-39-9
- US $0.00 / mg
- >95.00%
- Xian confluore Biological Technology Co., Ltd.