ZD 7155盐酸盐
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- CAS号:
- 146709-78-6
- 英文名:
- 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE
- 英文别名:
- ZD7155HCl;ZD 7155 HYDROCHLORIDE;ZD7155 hydrochloride >=97% (HPLC);ZD 7155 hydrochloride, 10 mM in DMSO;5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride;5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE;1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride
- 中文名:
- ZD 7155盐酸盐
- 中文别名:
- 化合物 T13390;ZD 7155盐酸盐;ZD 7155盐酸盐,10 MM DMSO 溶液;1-((2'-(2H-四氮唑-5-基)-[1,1'-联苯]-4-基)甲基)-5,7-二乙基-3,4-二氢-1,6-二氮杂萘-2(1H)-酮盐酸盐
- CBNumber:
- CB9360710
- 分子式:
- C26H27ClN6O
- 分子量:
- 474.99
- MOL File:
- 146709-78-6.mol
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ZD 7155盐酸盐化学性质
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储存条件:
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Inert atmosphere,2-8°C
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溶解度:
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DMSO: 10 mM
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形态:
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Powder
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颜色:
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White to yellow
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水溶解性:
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Soluble to 10 mM in water with gentle warming
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ZD 7155盐酸盐性质、用途与生产工艺
ZD 7155 hydrochloride是血管紧张素II受体1型 (AT1 receptor) 拮抗剂。
In conscious SD rats, ZD 7155 and losartan behave as competitive antagonists and the pressor response curve to angiotensin II is shifted to the right. Experiments in conscious SD rats also show that ZD 7155 is approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response (240 ng/kg; 10 min infusion). In addition, experiments with conscious rats demonstrate that ZD 7155 could suppress the angiotensin II-induced pressor response for approximately 24 h when ZD 7155 is administered intravenously in a 1.082 μmol/kg bolus dose and angiotensin II is given at 240 ng/kg (in a 10-min infusion). Experiments in conscious SHRs using ZD 7155 (1.082 mumol/kg) and losartan (6.495 mumol/kg) as intravenous boluses indicate that both ZD 7155 and the reference compound losartan exhibit a significant antihypertensive effect.
ZD 7155盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/02/08 | HY-102093 | ZD 7155盐酸盐
ZD 7155(hydrochloride) | 146709-78-6 | 5mg | 1500元 |
| 2025/02/08 | HY-102093 | ZD 7155盐酸盐
ZD 7155(hydrochloride) | 146709-78-6 | 10mM * 1mLin DMSO | 1570元 |
146709-78-6, ZD 7155盐酸盐 相关搜索:
- 抑制剂
- C26H26N6OHCl
- C26H27ClN6O
- ZD 7155盐酸盐,10 MM DMSO 溶液
- 化合物 T13390
- 1-((2'-(2H-四氮唑-5-基)-[1,1'-联苯]-4-基)甲基)-5,7-二乙基-3,4-二氢-1,6-二氮杂萘-2(1H)-酮盐酸盐
- ZD 7155盐酸盐
- 146709-78-6
- ZD 7155 hydrochloride, 10 mM in DMSO
- 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride
- ZD7155 hydrochloride >=97% (HPLC)
- ZD7155HCl
- 5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride
- 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE
- ZD 7155 HYDROCHLORIDE