化合物MN58B
|
|
|
- CAS号:
- 203192-01-2
- 英文名:
- MN58b
- 英文别名:
- MN58b;MN58b,inhibit,Apoptosis,Inhibitor,MN-58b;1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;Pyridinium, 1,?1'-?[1,?4-?butanediylbis(4,?1-?phenylenemethylene)?]?bis[4-?(dimethylamino)?-?, bromide (1:2);1-[[4-[4-[4-[[4-(dimethylamino)pyridin-1-ium-1-yl]methyl]phenyl]butyl]phenyl]methyl]-N,N-dimethylpyridin-1-ium-4-amine
- 中文名:
- 化合物MN58B
- 中文别名:
- 化合物MN58B;1,1'-((丁烷-1,4-二烷基双(4,1-亚苯基))双(亚甲基))双(4-(二甲氨基)吡啶-1-鎓)溴化物;1,1'-((丁烷-1,4-二烷基双(4,1-亚苯基))双(亚甲基))双(4-(二甲氨基)吡啶-1-鎓)溴化物
- CBNumber:
- CB94668218
- 分子式:
- C32H40BrN4+
- 分子量:
- 560.6
- MOL File:
- 203192-01-2.mol
|
|
|
化合物MN58B化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO:14.71(Max Conc. mg/mL);22.97(Max Conc. mM)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
White to off-white
-
|
化合物MN58B性质、用途与生产工艺
MN58b 是一种选择性的 choline kinase α (CHKα) 抑制剂，可抑制磷酸胆碱的合成。MN58b 通过诱导凋亡来减少细胞生长，并具有抗肿瘤活性。
The
IC
50
s of MN58b for parental and Gemcitabine-resistant Suit2 007 cells are 3.14 µM and 0.77 µM, respectively.
MN58b (1-5 µM; 72 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) has a marked effect on colony formation at 1 µM, and growth is completely abolished at 5 µM in all the cell lines.
MN58b ((1-10 µM; 24-48 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) induces apoptosis and this response correlates with CHKα expression.
Cell Viability Assay
|
Cell Line:
|
SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells
|
|
Concentration:
|
1 µM, 5 µM
|
|
Incubation Time:
|
72 hours
|
|
Result:
|
Inhibited cells growth.
|
Apoptosis Analysis
|
Cell Line:
|
SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells
|
|
Concentration:
|
1 µM, 2 µM, 5 µM, 10 µM
|
|
Incubation Time:
|
24 and 48 hours
|
|
Result:
|
Induced cell apoptosis.
|
MN58b (4 mg/kg; intraperitoneal injection; once a day; for 5 days; MF-1 nude mice) treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities.
|
Animal Model:
|
MF-1 nude mice with HT29 or MDA-MB-231 cells
|
|
Dosage:
|
4 mg/kg
|
|
Administration:
|
Intraperitoneal injection; once a day; for 5 days
|
|
Result:
|
Phosphomonoesters decreased significantly.
|
化合物MN58B
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-108431 | 化合物MN58B
MN58b | 203192-01-2 | 1mg | 3500元 |
| 2023/01/06 | S0998 | 化合物MN58B
MN58b | 203192-01-2 | 1mg | 6036.03元 |
203192-01-2, 化合物MN58B 相关搜索:
- 抑制剂
- 1,1'-((丁烷-1,4-二烷基双(4,1-亚苯基))双(亚甲基))双(4-(二甲氨基)吡啶-1-鎓)溴化物
- 1,1'-((丁烷-1,4-二烷基双(4,1-亚苯基))双(亚甲基))双(4-(二甲氨基)吡啶-1-鎓)溴化物
- 化合物MN58B
- 203192-01-2
- 1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide
- Pyridinium, 1,?1'-?[1,?4-?butanediylbis(4,?1-?phenylenemethylene)?]?bis[4-?(dimethylamino)?-?, bromide (1:2)
- 1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide
- MN58b,inhibit,Apoptosis,Inhibitor,MN-58b
- 1-[[4-[4-[4-[[4-(dimethylamino)pyridin-1-ium-1-yl]methyl]phenyl]butyl]phenyl]methyl]-N,N-dimethylpyridin-1-ium-4-amine
- MN58b