化合物MN58B
| 中文名称 | 化合物MN58B |
|---|---|
| 中文同义词 | 化合物MN58B;1,1'-((丁烷-1,4-二烷基双(4,1-亚苯基))双(亚甲基))双(4-(二甲氨基)吡啶-1-鎓)溴化物;1,1'-((丁烷-1,4-二烷基双(4,1-亚苯基))双(亚甲基))双(4-(二甲氨基)吡啶-1-鎓)溴化物 |
| 英文名称 | MN58b |
| 英文同义词 | MN58b;1-[[4-[4-[4-[[4-(dimethylamino)pyridin-1-ium-1-yl]methyl]phenyl]butyl]phenyl]methyl]-N,N-dimethylpyridin-1-ium-4-amine;MN58b,inhibit,Apoptosis,Inhibitor,MN-58b;1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;Pyridinium, 1,?1'-?[1,?4-?butanediylbis(4,?1-?phenylenemethylene)?]?bis[4-?(dimethylamino)?-?, bromide (1:2);1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide |
| CAS号 | 203192-01-2 |
| 分子式 | C32H40BrN4+ |
| 分子量 | 560.6 |
| EINECS号 | |
| 相关类别 | 抑制剂 |
| Mol文件 | 203192-01-2.mol |
| 结构式 |  |
化合物MN58B 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO：14.71（最大浓度 mg/mL）；22.97（最大浓度 mM） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Choline kinase α (CHKα)
The
IC
50
s of MN58b for parental and Gemcitabine-resistant Suit2 007 cells are 3.14 µM and 0.77 µM, respectively.
MN58b (1-5 µM; 72 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) has a marked effect on colony formation at 1 µM, and growth is completely abolished at 5 µM in all the cell lines.
MN58b ((1-10 µM; 24-48 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) induces apoptosis and this response correlates with CHKα expression.
Cell Viability Assay
| Cell Line: | SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells |
| Concentration: | 1 µM, 5 µM |
| Incubation Time: | 72 hours |
| Result: | Inhibited cells growth. |
Apoptosis Analysis
| Cell Line: | SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells |
| Concentration: | 1 µM, 2 µM, 5 µM, 10 µM |
| Incubation Time: | 24 and 48 hours |
| Result: | Induced cell apoptosis. |
MN58b (4 mg/kg; intraperitoneal injection; once a day; for 5 days; MF-1 nude mice) treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities.
| Animal Model: | MF-1 nude mice with HT29 or MDA-MB-231 cells |
| Dosage: | 4 mg/kg |
| Administration: | Intraperitoneal injection; once a day; for 5 days |
| Result: | Phosphomonoesters decreased significantly. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-108431 | 化合物MN58B MN58b | 203192-01-2 | 1mg | 3500元 |
| 2023/01/06 | S0998 | 化合物MN58B MN58b | 203192-01-2 | 1mg | 6036.03元 |