BAY 41-2272
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- CAS号:
- 256376-24-6
- 英文名:
- BAY 41-2272
- 英文别名:
- IN1523;UNII-34A162J6WB;Inhibitor,inhibit,Guanylate Cyclase,BAY 41 2272,BAY 412272,BAY 41-2272;3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3;5-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine;5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine;5-Cyclopropyl-2-[1-[(2-fluorophenyl)Methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyriMidinaMine;4-Pyrimidinamine, 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-;BAY 41-2272; 256376-24-6; UNII-34A162J6WB; IN1523; BAY-41-2272; 3-(4-AMINO-5-CYCLOPROPYLPYRIMIDIN-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3;4-B]PYRIDINE
- 中文名:
- BAY 41-2272
- 中文别名:
- PERFEMIKER]BAY 41-2272,99%;BAY 41-2272,可溶性鸟苷基环化酶(SGC)激活剂;5-环丙基-2-(1-(2-氟苄基)-1H-吡唑并[3,4-B]吡啶-3-基)嘧啶-4-胺
- CBNumber:
- CB9497944
- 分子式:
- C20H17FN6
- 分子量:
- 360.39
- MOL File:
- 256376-24-6.mol
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BAY 41-2272化学性质
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熔点:
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210.5-211.4 °C
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沸点:
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496.1±45.0 °C(Predicted)
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密度:
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1.49±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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DMSO: 26 mg/mL at 60 °C
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形态:
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solid
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酸度系数(pKa):
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2.71±0.10(Predicted)
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颜色:
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white
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BAY 41-2272性质、用途与生产工艺
BAY 41-2272是一种直接的,且独立于NO的水溶性guanylate cyclase (sGC)激动剂。
Target | Value |
Guanylate cyclase
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在体外,BAY 41-2272导致人和兔子海绵体浓度依赖性松弛,EC50分别为489.1 nM和406.3 nM。
在雌性自发性高血压大鼠中,BAY 41-2272 (10 mg/kg, p.o.)表现出抗血小板作用,大大降低了血压,并增加了存活率。在白色念珠菌感染的小鼠中,BAY 41-2272 (10 mg/kg, i.p.) 不仅增加巨噬细胞功能,且显著增加巨噬细胞依赖性细胞流入腹膜,减少死亡率。在db/db-/- II型糖尿病且肥胖的小鼠中,BAY 41-2272改善受损阴茎海绵体(CC)的松弛。
BAY 41-2272
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | S8128 | BAY 41-2272 BAY 41-2272 | 256376-24-6 | 5mg | 877.28元 |
2024/04/30 | S8128 | BAY 41-2272 BAY 41-2272 | 256376-24-6 | 25mg | 3082.52元 |
256376-24-6, BAY 41-2272 相关搜索:
- Pharmaceuticals, Intermediates & Fine Chemicals, Inhibitors
- 合成有机化合物配体
- 吡啶二胺
- BAY 41-2272,可溶性鸟苷基环化酶(SGC)激活剂
- PERFEMIKER]BAY 41-2272,99%
- 5-环丙基-2-(1-(2-氟苄基)-1H-吡唑并[3,4-B]吡啶-3-基)嘧啶-4-胺
- 256376-24-6
- 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine
- Inhibitor,inhibit,Guanylate Cyclase,BAY 41 2272,BAY 412272,BAY 41-2272
- 4-Pyrimidinamine, 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-
- 3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3
- UNII-34A162J6WB
- IN1523
- BAY 41-2272; 256376-24-6; UNII-34A162J6WB; IN1523; BAY-41-2272; 3-(4-AMINO-5-CYCLOPROPYLPYRIMIDIN-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3;4-B]PYRIDINE
- 5-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine
- 5-Cyclopropyl-2-[1-[(2-fluorophenyl)Methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyriMidinaMine