Human Endogenous Metabolite
Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes. Fucosterol shows cytotoxicity against T47D and HT29 cell lines with IC 50 values of 27.94 and 70.41 μg/ml, respectively.Fucosterol decreases cell HEK293, MCF-7, and SiHa cells proliferation with IC 50 values of 185.4, 43.3, and 34.0 µg/ml, respectively.
Cell Viability Assay
Fucosterol (oral adminstratin; 30mg/kg) causes a significant decrease in serum glucose concentrations, and exhibits an inhibition of sorbitol accumulations in the lenses.