ZZW-115
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- CAS号:
- 801991-87-7
- 英文名:
- 1-Piperazineethanamine, N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-
- 英文别名:
- ZZW-115;ZZW115,ZZW 115;1-Piperazineethanamine, N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-;N,N-Dimethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-amine
- 中文名:
- ZZW-115
- 中文别名:
- N,N-二甲基-2-(4-(3-(2-(三氟甲基)-10H-吩噻嗪-10-基)丙基)哌嗪-1-基)乙胺
- CBNumber:
- CB98104909
- 分子式:
- C24H31F3N4S
- 分子量:
- 464.59
- MOL File:
- 801991-87-7.mol
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ZZW-115性质、用途与生产工艺
ZZW-115 是一种有效的 NUPR1 抑制剂，Kd 为 2.1 μM，通过坏死和凋亡 (apoptosis) 诱导肿瘤细胞死亡。具有抗癌活性。
ZZW-115 (0.1-33 μM; 72 hours) is efficient in killing cancer cells, with an IC
50
in the range of 0.84 μM (ANOR) to 4.93 μM (HN14).
ZZW-115 (0-100 μM; 24-72 hours) is efficient to kill these tumor cells with an IC
50
in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells).
ZZW-115 induces pancreatic cell death by necrosis and apoptosis. ZZW-115 treatment induces a decrease in ATP production and induces a ROS overproduction.
LDH release is significantly higher in ZZW-115-treated cells (MiaPaCa-2, 02-063, LIPC, Foie8b, and HN14 cells) than in control cells in a concentration-dependent manner. Similarly, caspase 3/7 activity is also greater in ZZW-115-treated cells. These experiments demonstrated that ZZW-115 exerted both pronecrotic and proapoptotic effects.
Cell Viability Assay
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Cell Line:
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ANOR cells, MiaPaCa-2, 02-063, 01008, LIPC, 02136, HN01,01046, AOIPC, Foie8b, HN14 cells
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Concentration:
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0.1- 33 μM
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Incubation Time:
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72 hours
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Result:
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Was efficient in killing cancer cells, with an IC
50
in the range of 0.84 μM (ANOR) to 4.93 μM (HN14).
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Cell Proliferation Assay
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Cell Line:
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U87, A375, U2OS, SaOS-2, HT29, SK-CO-1, LS174T, H1299 and H358, HepG2, PC3, THP-1, Daudi, Jurkat and MDA-MB-231 cells
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Concentration:
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0-100 μM
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Incubation Time:
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24 or 72 hours
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Result:
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Was efficient to kill these tumor cells with an IC
50
in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells).
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ZZW-115 (0.5-5 mg/kg; injection; daily for 30 days) inhibits the growth of pancreatic xenografted tumors.
ZZW-115 (5 mg/kg for 30 days; immunocompetent C57BL/6 mice were orthotopically implanted with Panc02 cells) treatment shows the tumor size is almost unmeasurable in some cases.
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Animal Model:
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NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells
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Dosage:
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5, 2.5, 1.0, or 0.5 mg/kg
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Administration:
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Injection, daily for 30 days
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Result:
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When the mice were injected with 5 mg/kg ZZW-115, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatment.
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ZZW-115
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-111838 | ZZW-115 | | 1 mg | 1590元 |
| 2024/01/25 | HY-111838 | ZZW-115 | 801991-87-7 | 5mg | 3500元 |
801991-87-7, ZZW-115 相关搜索:
- 抑制剂
- C24H31F3N4S
- N,N-二甲基-2-(4-(3-(2-(三氟甲基)-10H-吩噻嗪-10-基)丙基)哌嗪-1-基)乙胺
- 801991-87-7
- N,N-Dimethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-amine
- ZZW115,ZZW 115
- ZZW-115
- 1-Piperazineethanamine, N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-