1-Piperazineethanamine, N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-
![1-Piperazineethanamine, N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]- Structure](CAS/20200611/GIF/801991-87-7.gif)
- CAS No.
- 801991-87-7
- Chemical Name:
- 1-Piperazineethanamine, N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-
- Synonyms
- ZZW-115;ZZW115,ZZW 115;1-Piperazineethanamine, N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-;N,N-Dimethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-amine
- CBNumber:
- CB98104909
- Molecular Formula:
- C24H31F3N4S
- Molecular Weight:
- 464.59
- MDL Number:
- MFCD34469422
- MOL File:
- 801991-87-7.mol
1-Piperazineethanamine, N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]- Chemical Properties,Uses,Production
Biological Activity
ZZW-115 is a potent NUPR1 inhibitor with Kd of 2.1 μM, which induces tumor cell death via necrosis and apoptosis. Has anticancer activity.
in vitro
ZZW-115 (0.1-33 μM; 72 hours) is efficient in killing cancer cells, with an IC 50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14 ).
ZZW-115 (0-100 μM; 24-72 hours) is efficient to kill these tumor cells with an IC 50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells).
ZZW-115 induces pancreatic cell death by necrosis and apoptosis. ZZW-115 treatment induces a decrease in ATP production and induces a ROS overproduction.
LDH release is significantly higher in ZZW-115-treated cells (MiaPaCa-2, 02-063, LIPC, Foie8b, and HN14 cells) than in control cells in a concentration-dependent manner. Similarly, caspase 3/7 activity is also greater in ZZW-115-treated cells. These experiments demonstrated that ZZW-115 exerted both pronecrotic and proapoptotic effects.
Cell Viability Assay
| Cell Line: | ANOR cells, MiaPaCa-2, 02-063, 01008, LIPC, 02136, HN01,01046, AOIPC, Foie8b, HN14 cells | < /tr>
| Concentration: | 0.1- 33 μM |
| Incubation Time: | 72 hours |
| Result: | Was efficient in killing cancer cells, with an IC 50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14). |
Cell Proliferation Assay
| Cell Line: | U87, A375, U2OS, SaOS-2, HT29, SK-CO-1, LS174T, H1299 and H358, HepG2, PC3, THP-1, Daudi, Jurkat and MDA-MB-231 cells |
| Concentration: | 0-100 μM |
| Incubation Time: | 24 or 72 hours |
| Result: | Was efficient to kill these tumor cells with an IC 50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM ( SaOS-2 cells). |
in vivo
ZZW-115 (0.5-5 mg/kg; injection; daily for 30 days) inhibits the growth of pancreatic xenografted tumors.
ZZW-115 (5 mg/kg for 30 days; immunocompetent C57BL /6 mice were orthotopically implanted with Panc02 cells) treatment showed the tumor size is almost unmeasurable in some cases.
| Animal Model: | NMRI -Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells |
| Dosage: | 5 , 2.5, 1.0, or 0.5 mg/kg |
| Administration: | Injection, daily for 30 days |
| Result: | When the mice were injected with 5 mg/kg, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatm ent. |
1-Piperazineethanamine, N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
1-Piperazineethanamine, N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3460 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 997 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3059 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6749 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |