5-(2-苯基)-吲哚-3-乙酸
|
|
|
- CAS号:
- 168649-23-8
- 英文名:
- 1H-Indole-3-acetic acid, 5-phenyl-
- 英文别名:
- 5-Ph-IAA;5-(2-phenyl)-indole-3-acetic acid;1H-Indole-3-acetic acid, 5-phenyl-;2-(5-Phenyl-1H-indol-3-yl)acetic acid;inhibit,antitumor,OsTIR1,Inhibitor,auxin,5 Ph IAA,5PhIAA,AID2
- 中文名:
- 5-(2-苯基)-吲哚-3-乙酸
- 中文别名:
- 化合物5-PH-IAA;5-苯基-吲哚-3-乙酸;5-苯基-1H-吲哚-3-乙酸;5-(2-苯基)-吲哚-3-乙酸;2-(5-苯基-1H-吲哚-3-基)乙酸
- CBNumber:
- CB98130298
- 分子式:
- C16H13NO2
- 分子量:
- 251.28
- MOL File:
- 168649-23-8.mol
|
|
|
5-(2-苯基)-吲哚-3-乙酸化学性质
-
沸点:
-
521.3±35.0 °C(Predicted)
-
|
-
密度:
-
1.291±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: 125 mg/mL (497.45 mM)
-
|
-
形态:
-
A solid
-
|
-
酸度系数(pKa):
-
4.47±0.30(Predicted)
-
|
-
颜色:
-
White to off-white
-
|
5-(2-苯基)-吲哚-3-乙酸性质、用途与生产工艺
5-Ph-IAA 是 IAA 的衍生物。5-Ph-IAA 是一种配体与 OsTIR1 (F74G) 突变体一起建立了生长素诱导的 degron 2 系统 (AID2)。AID2 诱导 mAID 融合蛋白的快速有效消耗，从而研究活细胞中的蛋白功能。AID2 可以抑制肿瘤。
HCT116 cells constitutively expressing OsTIR1(F74G) are exposed to 5-Ph-IAA (1 µM; 6 hours), leading to DHC1-mAC degradation, which means the AID2 system better than the original AID system in generating conditional mutant cell lines.
Western Blot Analysis
|
Cell Line:
|
HCT116 cells
|
|
Concentration:
|
1 µM
|
|
Incubation Time:
|
6 hours
|
|
Result:
|
Depleted DHC1-mAC efficiently in HCT116 cells constitutively expressing OsTIR1(F74G).
|
5-Ph-IAA (0-10 mg/kg; intraperitoneally injection; every day; 7 days), used for the AID2 system ,is sufficient to deplete mAID-BRD4 and TOP2A-mAC, leading to tumour suppression.
|
Animal Model:
|
Balb/c-nu female mice (7 weeks old; 16–20 g ) bearing mAID-BRD4 and TOP2A-mAC xenograft tumours cells
|
|
Dosage:
|
0 mg/kg, 1 mg/kg, 3 mg/kg and 10 mg/kg
|
|
Administration:
|
Intraperitoneally injection; every day; 7 days
|
|
Result:
|
Displayed significant tumour suppression of mAID-BRD4 xenografts and TOP2A-mAC xenografts.
|
5-(2-苯基)-吲哚-3-乙酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-134653 | 5-(2-苯基)-吲哚-3-乙酸
5-Ph-IAA | 168649-23-8 | 5mg | 2000元 |
| 2024/04/30 | HY-134653 | 5-(2-苯基)-吲哚-3-乙酸
5-Ph-IAA | | 10 mM * 1 mLin DMSO | 2200元 |
168649-23-8, 5-(2-苯基)-吲哚-3-乙酸 相关搜索:
- 5-苯基-吲哚-3-乙酸
- 2-(5-苯基-1H-吲哚-3-基)乙酸
- 5-苯基-1H-吲哚-3-乙酸
- 化合物5-PH-IAA
- 5-(2-苯基)-吲哚-3-乙酸
- 168649-23-8
- 2-(5-Phenyl-1H-indol-3-yl)acetic acid
- inhibit,antitumor,OsTIR1,Inhibitor,auxin,5 Ph IAA,5PhIAA,AID2
- 5-(2-phenyl)-indole-3-acetic acid
- 5-Ph-IAA
- 1H-Indole-3-acetic acid, 5-phenyl-