5-(2-苯基)-吲哚-3-乙酸
中文名称 | 5-(2-苯基)-吲哚-3-乙酸 |
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中文同义词 | 5-(2-苯基)-吲哚-3-乙酸;化合物5-PH-IAA;5-苯基-1H-吲哚-3-乙酸;2-(5-苯基-1H-吲哚-3-基)乙酸;5-苯基-吲哚-3-乙酸 |
英文名称 | 1H-Indole-3-acetic acid, 5-phenyl- |
英文同义词 | 1H-Indole-3-acetic acid, 5-phenyl-;5-Ph-IAA;5-(2-phenyl)-indole-3-acetic acid;inhibit,antitumor,OsTIR1,Inhibitor,auxin,5 Ph IAA,5PhIAA,AID2;2-(5-Phenyl-1H-indol-3-yl)acetic acid |
CAS号 | 168649-23-8 |
分子式 | C16H13NO2 |
分子量 | 251.28 |
EINECS号 | |
相关类别 | |
Mol文件 | 168649-23-8.mol |
结构式 |
5-(2-苯基)-吲哚-3-乙酸 性质
沸点 | 521.3±35.0 °C(Predicted) |
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密度 | 1.291±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:125 mg/mL(497.45 mM) |
形态 | 固体 |
酸度系数(pKa) | 4.47±0.30(Predicted) |
颜色 | 白色至米白色 |
HCT116 cells constitutively expressing OsTIR1(F74G) are exposed to 5-Ph-IAA (1 µM; 6 hours), leading to DHC1-mAC degradation, which means the AID2 system better than the original AID system in generating conditional mutant cell lines.
Western Blot Analysis
Cell Line: | HCT116 cells |
Concentration: | 1 µM |
Incubation Time: | 6 hours |
Result: | Depleted DHC1-mAC efficiently in HCT116 cells constitutively expressing OsTIR1(F74G). |
5-Ph-IAA (0-10 mg/kg; intraperitoneally injection; every day; 7 days), used for the AID2 system ,is sufficient to deplete mAID-BRD4 and TOP2A-mAC, leading to tumour suppression.
Animal Model: | Balb/c-nu female mice (7 weeks old; 16–20 g ) bearing mAID-BRD4 and TOP2A-mAC xenograft tumours cells |
Dosage: | 0 mg/kg, 1 mg/kg, 3 mg/kg and 10 mg/kg |
Administration: | Intraperitoneally injection; every day; 7 days |
Result: | Displayed significant tumour suppression of mAID-BRD4 xenografts and TOP2A-mAC xenografts. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-134653 | 5-(2-苯基)-吲哚-3-乙酸 5-Ph-IAA | 168649-23-8 | 5mg | 2000元 |
2024/08/19 | HY-134653 | 5-(2-苯基)-吲哚-3-乙酸 5-Ph-IAA | 10 mM * 1 mLin DMSO | 2200元 |