AC-FLTD-CMK
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- CAS号:
- 2376255-48-8
- 英文名:
- INDEX NAME NOT YET ASSIGNED
- 英文别名:
- 中文名:
- AC-FLTD-CMK
- 中文别名:
- CBNumber:
- CB98225653
- 分子式:
- C26H37ClN4O8
- 分子量:
- 569.05
- MOL File:
- 2376255-48-8.mol
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AC-FLTD-CMK化学性质
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沸点:
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962.7±65.0 °C(Predicted)
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密度:
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1.275±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C, protect from light, stored under nitrogen
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溶解度:
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Soluble to 1 mg/ml in DMSO
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酸度系数(pKa):
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3.93±0.19(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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AC-FLTD-CMK性质、用途与生产工艺
Ac-FLTD-CMK 是胃泌素 D (GSDMD) 衍生的抑制剂，是炎症性 caspases 的特异性抑制剂。Ac-FLTD-CMK 对 caspases-1 (IC50 为 46.7 nM)，caspases-4 (IC50 为 1.49 μM)，caspases-5 (IC50 为 329 nM) 和 caspases-11 均有效，但对凋亡相关的 caspase-3 无效。
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Caspase-1
46.7 nM (IC
50
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Caspase-4
1.49 μM (IC
50
)
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Caspase-5
329 nM (IC
50
)
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Caspase-11
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Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts.
AC-FLTD-CMK
上下游产品信息
上游原料
下游产品
2376255-48-8, AC-FLTD-CMK 相关搜索:
- 药靶配体
- C26H37ClN4O8
- 2376255-48-8