AC-FLTD-CMK
| 中文名称 | AC-FLTD-CMK |
|---|---|
| 中文同义词 | 化合物AC-FLTD-CMK |
| 英文名称 | INDEX NAME NOT YET ASSIGNED |
| 英文同义词 | |
| CAS号 | 2376255-48-8 |
| 分子式 | C26H37ClN4O8 |
| 分子量 | 569.05 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2376255-48-8.mol |
| 结构式 |  |
AC-FLTD-CMK 性质
| 沸点 | 962.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.275±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C, protect from light, stored under nitrogen |
| 溶解度 | 在 DMSO 中的溶解度为 1 mg/ml |
| 酸度系数(pKa) | 3.93±0.19(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
|
Caspase-1 46.7 nM (IC 50 ) |
Caspase-4 1.49 μM (IC 50 ) |
Caspase-5 329 nM (IC 50 ) |
Caspase-11
|
Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts.