Losartan Carboxaldehyde

Losartan Carboxaldehyde Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A₂ and prostaglandin F_2α . Losartan carboxaldehyde can also act as a partial agonist (EC₅₀ = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.

Chemische Eigenschaften

Yellow Solid

Verwenden

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.[Cayman Chemical]

Losartan Carboxaldehyde Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Losartan Carboxaldehyde Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9215	55
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	13552	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32079	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30241	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58

114798-36-6()Verwandte Suche:

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• 2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde
• DUP 167
• EXP 3179
• Losartan CarboxaldehydeDiscontinued see product # L470505
• Losartan Carboxaldehyde
• 2-(Butyl-d3)-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde
• Losartan Carboxaldehyde-d3
• Losartan EP IMpurity K (LosaratnCarboxaldehyde)
• Losartan EP IMpurity K
• Losartan Related CoMpound C
• Losartan Aldehyde
• 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde
• Losartan Related Compound C (2-Butyl-4-chloro-1-[[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imi (1370495)
• Losartan Carboxaldehyde_x000b_Discontinued see product # L470505
• Losartan EP Impurity K/ Losartan Related Compound C (Losartan Aldehyde)
• Allisartan Isoproxil impurity II
• 1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
• Losartan EP Impurity K:Losartan Impurity K
• Losartan Impurity 11(Losartan EP Impurity K)
• 2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formaldehyde
• Losartan Impurity K (EP)
• 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carbaldehyde
• Losartan EP Impurity K (Losartan Carboxaldehyde)
• Losartan USP Related Compound C
• DuP 167,EXP-3179,DuP-167,Inhibitor,COX,AT1-R–blocking,intermediate aldehyde metabolite,Cyclooxygenase,COX-2,EXP3179,inhibit,EXP 3179,Losartan,Losartan Carboxaldehyde,anti-inflammatory,DuP167
• Losartan Potassium EP Impurity K
• Losartan EP Impurity K Losartan USP RC C
• 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde
• Losartan EP Impurity K (Losartan USP Related Compound C, Losartan Carboxaldehyde)
• 114798-36-6
• 14798-36-6
• C22H21ClN6O
• Intermediates & Fine Chemicals
• Isotope Labelled Compounds
• Metabolites & Impurities
• Pharmaceuticals
• Isotope Labeled Compounds