Baxitozine

Baxitozine Struktur
84386-11-8
CAS-Nr.
84386-11-8
Englisch Name:
Baxitozine
Synonyma:
RU-38086;Baxitozine;(E)-4-Oxo-4-(3,4,5-trimethoxyphenyl)-2-butenoic acid;2-Butenoic acid, 4-oxo-4-(3,4,5-trimethoxyphenyl)-, (2E)-
CBNumber:
CB01178081
Summenformel:
C13H14O6
Molgewicht:
266.25
MOL-Datei:
84386-11-8.mol

Baxitozine Eigenschaften

Sicherheit

Baxitozine Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Baxitozine,ZYF Pharm Chemical

Manufacturing Process

29.6 g of glyoxylic acid of 50% by weight are heated in water under reduced pressure until elimination of 80% of the water present, whereupon, after cooling, 84.1 g of 3,4,5-trimethoxy acetophenone are introduced into the reaction mixture. Heating is effected for 2 h at 95°-100°C under reduced pressure (about 50 mm/Hg), at the same time distilling off the residual water present.
After cooling of the medium, 120 ml of water containing 11.6 g of sodium carbonate and ether are introduced, the aqueous phase is decanted and washed with : ether, whereupon the aqueous phase is acidified to a pH of 1 with 50% hydrochloric acid. The desired product is extracted with ethyl acetate. After elimination of the extraction solvent 31.5 g of the 4-(3,4,5- trimethoxyphenyl)-4-oxo-2-hydroxy butanoic acid, melting point 119°-120° are obtained (recrystallization from 1,2-dichloroethane).
15.8 g of 4-(3,4,5-trimethoxyphenyl)-4-oxo-2-hydroxy butanoic acid, 20 ml of acetic acid and 20 ml of concentrated hydrochloric acid (d-1.18) are heated for 2.5 h under reflux. The reaction medium is cooled and precipitated by water. The precipitate formed is filtered off. 10.5 g of the (E)-4-(3,4,5- trimethoxyphenyl)-4-oxo-2-butenoic acid, melting point 140°C are obtained (recrystallization from ethanol-water 1:1).

Therapeutic Function

Gastric cytoprotective; Antiulcer

Baxitozine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Baxitozine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822
czbjpharma@126.com China 18488 58

84386-11-8()Verwandte Suche:


  • Baxitozine
  • (E)-4-Oxo-4-(3,4,5-trimethoxyphenyl)-2-butenoic acid
  • RU-38086
  • 2-Butenoic acid, 4-oxo-4-(3,4,5-trimethoxyphenyl)-, (2E)-
  • 84386-11-8
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