nemorosone

351416-47-2

CAS-Nr.: 351416-47-2

Englisch Name:: nemorosone

Synonyma:: nemorosone;(1R,5S,7S)-rel-5-benzoyl-4-hydroxy-6,6-dimethyl-1,3,7-tris(3-methyl-2-buten-1-yl)-bicyclo[3.3.1]non-3-ene-2,9-dione;Bicyclo[3.3.1]non-3-ene-2,9-dione, 1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methyl-2-butenyl)-, (1R,5R,7S)- (9CI)

CBNumber:: CB01331583

Summenformel:: C33H42O4

Molgewicht:: 502.68

MOL-Datei:: 351416-47-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 5

nemorosone Eigenschaften

Siedepunkt:: 608.9±55.0 °C(Predicted)

Dichte: 1.077±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: DMF:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)

Aggregatzustand: A crystalline solid

pka: 4.50±1.00(Predicted)

Sicherheit

nemorosone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties. Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC₅₀s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC₅₀ = >40 μM). It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nemorosone also inhibits growth of Capan-1, AsPC-1, and MIA-PaCa-2 pancreatic cancer cells (IC₅₀s = 4.5-5.0 μM following a 72-hour treatment) but not human dermal and foreskin fibroblasts (IC₅₀s = >35 μM). It induces apoptosis, abolishes the mitochondrial membrane potential, and increases cytosolic calcium concentration in pancreatic cancer cells in a dose-dependent manner. Nemorosone activates the caspase cascade in a dose-dependent manner and inhibits cell cycle progression, increasing the proportion of cells in the G₀/G₁ phase, in both neuroblastoma and pancreatic cancer cells. Nemorosone (50 mg/kg, i.p., per day) also reduces tumor growth in an MIA-PaCa-2 mouse xenograft model.

nemorosone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

nemorosone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 5)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8739	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28091	58

nemorosone
Bicyclo[3.3.1]non-3-ene-2,9-dione, 1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methyl-2-butenyl)-, (1R,5R,7S)- (9CI)
(1R,5S,7S)-rel-5-benzoyl-4-hydroxy-6,6-dimethyl-1,3,7-tris(3-methyl-2-buten-1-yl)-bicyclo[3.3.1]non-3-ene-2,9-dione
351416-47-2